{"id":"W3184116075","doi":"10.1038/s41467-021-24661-0","title":"The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Government of Canada; Vetenskapsrådet; National Institutes of Health; Jewish General Hospital; National Institute of Diabetes and Digestive and Kidney Diseases; McGill University","keywords":"KRAS; Carcinogenesis; Lung cancer; Cancer research; Adenocarcinoma; Integrated stress response; Cancer; MAPK/ERK pathway; Kinase; Biology; Medicine; Oncology; Translation (biology); Internal medicine; Cell biology; Colorectal cancer; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001936883,0.0002466219,0.0002342725,0.0002101883,0.0001678309,0.0002802748,0.0001386242,0.0002280342,0.001171709],"category_scores_gemma":[0.0001017315,0.0000650069,0.0001967692,0.0001182203,0.0002204545,0.0001679918,0.0002435668,0.0005356792,0.0002655539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002085672,"about_ca_system_score_gemma":0.0001983838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001473428,"about_ca_topic_score_gemma":0.0003560608,"domain_scores_codex":[0.9999114,0.00001976365,0.000008296503,0.00001563279,0.00002368178,0.00002113793],"domain_scores_gemma":[0.9999219,0.00001150135,0.0000247163,0.00001139248,0.000007121622,0.00002333285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003404985,0.0001395323,0.0009960266,0.0001011889,0.00001216265,0.00016061,0.00001586593,0.0002558484,0.9786906,0.0006259806,0.0001736935,0.0184881],"study_design_scores_gemma":[0.00006946555,0.005035301,0.0104998,0.000026928,0.00003957564,0.002804987,0.00005865351,0.001476895,0.9681495,0.0006588129,0.01116671,0.00001334151],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.976587,0.01019347,0.007168163,0.0006167076,0.0001099645,0.00006940376,0.0001928791,0.0002437529,0.004818686],"genre_scores_gemma":[0.9950087,0.002260149,0.001280641,0.00007381022,0.00002112902,0.00002305769,0.0001243053,0.00001150778,0.00119671],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001171709,"threshold_uncertainty_score":0.00391978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01302228752088267,"score_gpt":0.3126145857436025,"score_spread":0.2995922982227198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}