{"id":"W3184202165","doi":"10.1101/2021.07.22.453419","title":"Harnessing the functional diversity of plant cystatins to design inhibitor variants highly active against herbivorous arthropod digestive proteases","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Insect Resistance and Genetics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Cystatin; Proteases; Protease; Biology; Cystatin C; Biochemistry; Mutagenesis; Computational biology; Enzyme; Gene; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003034167,0.0004525491,0.0004059605,0.00008960754,0.0004566313,0.0001172978,0.0004241758,0.0004155898,0.000007656538],"category_scores_gemma":[0.000270561,0.000411545,0.0001662627,0.0002515051,0.0001933375,0.00001265666,0.001205969,0.0003942628,0.000004850143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000119516,"about_ca_system_score_gemma":0.001169397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006300852,"about_ca_topic_score_gemma":0.00002591313,"domain_scores_codex":[0.9976203,0.0002842718,0.0003752953,0.0008850603,0.0004148044,0.0004202611],"domain_scores_gemma":[0.997762,0.00004959286,0.0003965948,0.0008607369,0.0007615074,0.0001695795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004684519,0.0002177701,0.002648784,0.0001669114,0.0003308366,0.00005890803,0.00007410057,0.001959056,0.9936382,0.00001816058,0.0004090987,0.000009685101],"study_design_scores_gemma":[0.0004099013,0.0001845421,0.1244187,0.0003654786,0.0001039529,6.841232e-8,0.00004880341,0.00005770691,0.8731804,9.689646e-7,0.0007426323,0.0004868474],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9772092,0.001018854,0.01902263,0.0001281441,0.0007460336,0.001055703,0.0007766063,0.00003580181,0.000007016368],"genre_scores_gemma":[0.9930205,0.0002527819,0.005708908,0.0002910623,0.0005000044,0.0001468438,0.000008974217,0.00006183658,0.000009041751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1217699,"threshold_uncertainty_score":0.9998336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01532218578479647,"score_gpt":0.2075832893115879,"score_spread":0.1922611035267914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}