{"id":"W3184249037","doi":"10.1016/j.vaccine.2021.07.034","title":"An enveloped virus-like particle vaccine expressing a stabilized prefusion form of the SARS-CoV-2 spike protein elicits highly potent immunity","year":2021,"lang":"en","type":"article","venue":"Vaccine","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; National Research Council Canada; Variation Biotechnologies (Canada)","funders":"Government of Canada; Innovation, Science and Economic Development Canada","keywords":"Virology; Spike Protein; Virus; Coronavirus; Neutralizing antibody; Antibody; Immunization; Titer; Neutralization; Biology; Virus-like particle; Viral envelope; Immunity; Nidovirales; Antibody titer; Immune system; Coronavirus disease 2019 (COVID-19); Medicine; Immunology; Recombinant DNA; Gene; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002059408,0.0003836775,0.0002568536,0.0001511236,0.0000753075,0.0002024126,0.000138081,0.0002866078,0.0005656497],"category_scores_gemma":[0.0001039481,0.00009161824,0.0002022037,0.00009425243,0.0001294772,0.0001701074,0.000144855,0.0004043109,0.0001352961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001480464,"about_ca_system_score_gemma":0.0002030979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002495412,"about_ca_topic_score_gemma":0.0004347235,"domain_scores_codex":[0.9998931,0.00001643223,0.000008554596,0.000015727,0.00003171881,0.00003443077],"domain_scores_gemma":[0.9999523,0.0000094445,0.00001098395,0.000004069761,0.000009804818,0.00001340167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001036722,0.0001482038,0.0001569545,0.0000206128,0.000004246987,0.00002121166,0.000007450524,0.0001909038,0.9984792,0.00003234549,0.00001477805,0.0008204089],"study_design_scores_gemma":[0.0001173139,0.009250239,0.003083375,0.000006132172,0.00002819454,0.0001938218,0.00002120233,0.001680652,0.9843792,0.00004199252,0.001192779,0.00000510204],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998442,0.0002268315,0.0008904689,0.00002512126,0.00001453462,0.00003046522,0.00006771527,0.00001558349,0.0002873482],"genre_scores_gemma":[0.9970878,0.0002194996,0.001576591,0.00003361407,0.000007970894,0.00002042295,0.0003405093,0.00000452107,0.0007091276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005656497,"threshold_uncertainty_score":0.001892269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.044402272666055,"score_gpt":0.335481202241001,"score_spread":0.291078929574946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}