{"id":"W3184249037","doi":"10.1016/j.vaccine.2021.07.034","title":"An enveloped virus-like particle vaccine expressing a stabilized prefusion form of the SARS-CoV-2 spike protein elicits highly potent immunity","year":2021,"lang":"en","type":"article","venue":"Vaccine","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; National Research Council Canada; Variation Biotechnologies (Canada)","funders":"Government of Canada; Innovation, Science and Economic Development Canada","keywords":"Virology; Spike Protein; Virus; Coronavirus; Neutralizing antibody; Antibody; Immunization; Titer; Neutralization; Biology; Virus-like particle; Viral envelope; Immunity; Nidovirales; Antibody titer; Immune system; Coronavirus disease 2019 (COVID-19); Medicine; Immunology; Recombinant DNA; Gene; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007875495,0.0003409347,0.0006757212,0.0001303156,0.0002875326,0.00006442535,0.0004797665,0.0001764412,0.00006846071],"category_scores_gemma":[0.000562228,0.0002312292,0.0002345538,0.001067119,0.00002965684,0.0002976875,0.0005053012,0.0005413672,0.00002840341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001777292,"about_ca_system_score_gemma":0.0005667816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007941743,"about_ca_topic_score_gemma":0.0005743303,"domain_scores_codex":[0.9967955,0.0003683209,0.0007882447,0.0005653719,0.0008228548,0.0006597214],"domain_scores_gemma":[0.9971969,0.0001041244,0.0002378115,0.001720872,0.0006531547,0.00008718398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0017943,0.001115615,0.01707668,0.0002468534,0.00007367841,0.00006499785,0.0008244296,9.773856e-7,0.9717967,0.00004985469,0.0001679753,0.006787947],"study_design_scores_gemma":[0.006426909,0.0005511984,0.04125239,0.0003938311,0.00009402074,0.00005419974,0.0002659303,0.001509313,0.9377074,0.0001887233,0.01132154,0.0002345846],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958256,0.0007289565,0.00021334,0.001188872,0.0001220704,0.001488154,0.00001813876,0.0001229557,0.0002919074],"genre_scores_gemma":[0.9923495,0.00001933061,0.0007184144,0.006447708,0.0001355669,0.0001315624,0.00001451893,0.00006566085,0.0001177386],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03408933,"threshold_uncertainty_score":0.9429253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.044402272666055,"score_gpt":0.335481202241001,"score_spread":0.291078929574946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}