{"id":"W3184257628","doi":"10.1371/journal.ppat.1009748","title":"Adaptive selection of a prion strain conformer corresponding to established North American CWD during propagation of novel emergent Norwegian strains in mice expressing elk or deer prion protein","year":2021,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Food Inspection Agency","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Chronic wasting disease; Prion protein; Biology; Strain (injury); Transmissible spongiform encephalopathy; Virology; Scrapie; Horizontal transmission; Disease; Virus; Medicine; Anatomy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001579489,0.0001878646,0.0002609453,0.0001577528,0.00007231034,0.00002121188,0.0001162951,0.00007608971,0.00003236414],"category_scores_gemma":[0.0003783973,0.000188043,0.00008910243,0.0006140159,0.0000447988,0.00002279984,0.0001008315,0.0001056545,6.264348e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000663559,"about_ca_system_score_gemma":0.0003172711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003323912,"about_ca_topic_score_gemma":0.0005487871,"domain_scores_codex":[0.9984596,0.0001065869,0.0004640056,0.0004191996,0.0002535347,0.0002970855],"domain_scores_gemma":[0.9990438,0.00001056093,0.0003370695,0.0001979282,0.0002932998,0.0001173276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007171403,0.000308754,0.007203139,0.0001523573,0.00004902105,0.000007820125,0.0005060257,0.001222786,0.9773551,0.00000670222,0.000001946817,0.01246921],"study_design_scores_gemma":[0.000712992,0.0004161026,0.07277185,0.0002592789,0.00003168467,0.000007032985,0.0008226933,0.001101025,0.9236125,0.000001186818,0.00003709879,0.0002265721],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925338,0.0000917883,0.006200104,0.00003039206,0.0000307118,0.0008613422,0.0002229354,0.00001107315,0.00001786612],"genre_scores_gemma":[0.9901888,0.00007080024,0.009337341,0.00002287348,0.00005999355,0.00009765081,0.000148041,0.00002923306,0.00004531652],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06556871,"threshold_uncertainty_score":0.7668171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01988800623601512,"score_gpt":0.2553877243662453,"score_spread":0.2354997181302302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}