{"id":"W3184354838","doi":"10.4049/jimmunol.2100446","title":"The Quality of SARS-CoV-2–Specific T Cell Functions Differs in Patients with Mild/Moderate versus Severe Disease, and T Cells Expressing Coinhibitory Receptors Are Highly Activated","year":2021,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Government of Canada; Fast Grants","keywords":"Immunology; T cell; Immune system; Receptor; TIGIT; Immunogenicity; CD8; Medicine; Cytotoxic T cell; Cytokine; Biology; Internal medicine; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003346344,0.0003674557,0.000396565,0.0004669048,0.0002991908,0.0004965502,0.0001226451,0.0003113078,0.002399327],"category_scores_gemma":[0.000784448,0.0001272399,0.0002242594,0.0003142797,0.0002443875,0.0003663281,0.0003355425,0.0003186949,0.0003902817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001396678,"about_ca_system_score_gemma":0.00007518967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002657028,"about_ca_topic_score_gemma":0.0003021507,"domain_scores_codex":[0.9996785,0.00007850023,0.00005571725,0.00007281065,0.00003857218,0.00007583322],"domain_scores_gemma":[0.9995572,0.0001072162,0.0001549556,0.00003930616,0.0000463724,0.00009500021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002596121,0.0001029249,0.9357148,0.0000752446,0.00008825337,0.001150828,0.0002934723,0.0001330071,0.05009485,0.00008178371,0.0002448994,0.009423744],"study_design_scores_gemma":[0.00003209745,0.0009512124,0.9892437,0.0000164751,0.00004936329,0.004160346,0.0002921474,0.0003197992,0.004179268,0.00006528382,0.0006820217,0.000008348299],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990348,0.000233098,0.0001131113,0.00001356563,0.000003556368,0.0000075802,0.00007767499,0.000004797982,0.0005119061],"genre_scores_gemma":[0.9996742,0.00004196998,0.00005121255,0.00001708146,0.000007863457,0.000004498342,0.0001162399,0.000001831912,0.00008509178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002399327,"threshold_uncertainty_score":0.00802654,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06165829487622972,"score_gpt":0.3525734833711803,"score_spread":0.2909151884949506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}