{"id":"W3184354838","doi":"10.4049/jimmunol.2100446","title":"The Quality of SARS-CoV-2–Specific T Cell Functions Differs in Patients with Mild/Moderate versus Severe Disease, and T Cells Expressing Coinhibitory Receptors Are Highly Activated","year":2021,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Government of Canada; Fast Grants","keywords":"Immunology; T cell; Immune system; Receptor; TIGIT; Immunogenicity; CD8; Medicine; Cytotoxic T cell; Cytokine; Biology; Internal medicine; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007219895,0.0001370722,0.0004613724,0.00008372442,0.0002208408,0.00001514529,0.0001425942,0.00006790196,0.00001192816],"category_scores_gemma":[0.002402448,0.00007148586,0.00008886728,0.0002247927,0.0006522653,0.000080258,0.0001557092,0.0007076332,0.000001723732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001618771,"about_ca_system_score_gemma":0.0003125923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002525759,"about_ca_topic_score_gemma":0.00001729606,"domain_scores_codex":[0.9977385,0.0008954231,0.0005880875,0.0001444753,0.0003822088,0.0002512428],"domain_scores_gemma":[0.9926149,0.005844948,0.0005459382,0.0003373616,0.0005938179,0.00006305741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.1212961,0.001454016,0.0656046,0.0002657075,0.00129503,0.00005774917,0.001311759,0.0002136696,0.8022555,0.00001016401,0.00252922,0.003706449],"study_design_scores_gemma":[0.01413895,0.001414049,0.84385,0.0005270647,0.00019358,0.000002221784,0.002358177,0.00001001014,0.1351831,0.00006397876,0.002108236,0.0001507178],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946784,0.00235884,0.00003012861,0.002259657,0.000427519,0.0001792987,0.00001224959,0.000005227801,0.00004869507],"genre_scores_gemma":[0.9969464,0.002747181,0.00003077758,0.0001023644,0.00004562978,0.000002614477,0.00000264647,0.0000136003,0.0001087734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7782453,"threshold_uncertainty_score":0.3074353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06165829487622972,"score_gpt":0.3525734833711803,"score_spread":0.2909151884949506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}