{"id":"W3184365720","doi":"10.1186/s13072-021-00410-x","title":"Epigenetic rewriting at centromeric DNA repeats leads to increased chromatin accessibility and chromosomal instability","year":2021,"lang":"en","type":"article","venue":"Epigenetics & Chromatin","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Muséum National d'Histoire Naturelle; Centre National de la Recherche Scientifique; Ministère de l'Éducation Nationale; Ministère de l'Education Nationale, de l'Enseignement Supérieur et de la Recherche; Institut National de la Santé et de la Recherche Médicale","keywords":"Biology; Chromatin; Centromere; Genetics; Heterochromatin; Epigenetics; Histone; Heterochromatin protein 1; Chromosome instability; Constitutive heterochromatin; Chromosome; Cell biology; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005006587,0.0004443871,0.0005832291,0.00003000892,0.0007829191,0.0002178455,0.0004114758,0.000222224,0.002475667],"category_scores_gemma":[0.0008034463,0.0002574904,0.0001783359,0.0009901008,0.0001709698,0.0001092085,0.0008087605,0.00019475,0.0001508407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002185886,"about_ca_system_score_gemma":0.00009524317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002593751,"about_ca_topic_score_gemma":0.002726722,"domain_scores_codex":[0.9960057,0.0004821051,0.000930427,0.001239095,0.0005547292,0.0007880108],"domain_scores_gemma":[0.9979131,0.0005343889,0.0002592527,0.0004399199,0.000254473,0.0005988507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0000195605,0.0002446019,0.07572708,0.00005601903,0.00002186437,0.00002719202,0.0002950761,0.00001702176,0.9072989,0.00003908379,0.0001034321,0.01615016],"study_design_scores_gemma":[0.0003508427,0.0002543238,0.7708993,0.00007096909,0.00003945795,0.00005364976,0.0001688518,0.0002967723,0.2244772,0.0002780773,0.00266285,0.0004476753],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942977,0.001065305,0.00001446872,0.001620845,0.0001812126,0.0006236731,0.0002429239,0.0001630192,0.001790831],"genre_scores_gemma":[0.9941865,0.0001288375,0.00406355,0.0004653326,0.0003983318,0.00008225634,0.0002827476,0.000008374289,0.0003840222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6951723,"threshold_uncertainty_score":0.9999877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01599270140189868,"score_gpt":0.2366995147853206,"score_spread":0.2207068133834219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}