{"id":"W3184365720","doi":"10.1186/s13072-021-00410-x","title":"Epigenetic rewriting at centromeric DNA repeats leads to increased chromatin accessibility and chromosomal instability","year":2021,"lang":"en","type":"article","venue":"Epigenetics & Chromatin","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Muséum National d'Histoire Naturelle; Centre National de la Recherche Scientifique; Ministère de l'Éducation Nationale; Ministère de l'Education Nationale, de l'Enseignement Supérieur et de la Recherche; Institut National de la Santé et de la Recherche Médicale","keywords":"Biology; Chromatin; Centromere; Genetics; Heterochromatin; Epigenetics; Histone; Heterochromatin protein 1; Chromosome instability; Constitutive heterochromatin; Chromosome; Cell biology; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001044132,0.0002580999,0.0002040918,0.00014343,0.0001105656,0.0002261826,0.0002298586,0.0002754621,0.002012346],"category_scores_gemma":[0.000163991,0.0001106089,0.0002304645,0.0001154819,0.0002097557,0.0001037364,0.0003737229,0.0004030066,0.0003417571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001553349,"about_ca_system_score_gemma":0.00009131471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00021386,"about_ca_topic_score_gemma":0.0003064242,"domain_scores_codex":[0.9998838,0.00001513267,0.00001205036,0.00003499614,0.00003384548,0.00002025131],"domain_scores_gemma":[0.9998493,0.00002642193,0.00005824203,0.00003017338,0.00001121108,0.00002452831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003858966,0.00001087719,0.000209644,0.00002230165,0.000006331746,0.00006694424,0.000006022522,0.00005031097,0.9988849,0.00005392094,0.000013989,0.0006362633],"study_design_scores_gemma":[0.000009189657,0.0001804696,0.007559181,0.00000593724,0.0000253836,0.0005547215,0.00002165727,0.0006269011,0.989325,0.00007699596,0.001610668,0.000003804594],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933819,0.001406151,0.003774906,0.00006887539,0.00002592147,0.00001439657,0.0001961495,0.0001393762,0.0009923746],"genre_scores_gemma":[0.9970005,0.0004473242,0.0006456287,0.00003804516,0.000006967705,0.00001457557,0.0002237241,0.00002013254,0.001602905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002012346,"threshold_uncertainty_score":0.006731927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01599270140189868,"score_gpt":0.2366995147853206,"score_spread":0.2207068133834219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}