{"id":"W3184512278","doi":"10.1101/2021.07.16.452686","title":"Very Long-Chain Unsaturated Sphingolipids Mediate Oleate-Induced Rat β-Cell Proliferation","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute; Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; National Institutes of Health; Association pour la Recherche sur le Diabète; Société Francophone du Diabète; Institut de Cardiologie de Montréal; American Heart Association; American Diabetes Association","keywords":"Sphingolipid; Cell growth; Sphingosine; Biochemistry; Gene knockdown; Biology; Cell; Cell biology; Sphingosine kinase; Chemistry; Sphingosine-1-phosphate; Apoptosis; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000132429,0.0004366246,0.0002051946,0.0002849808,0.0001004245,0.0001933918,0.0001236406,0.0001636656,0.001590993],"category_scores_gemma":[0.00008470928,0.0001194774,0.0002487523,0.0001356565,0.0001540101,0.0001622129,0.0002355438,0.0004581135,0.0004407821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001622132,"about_ca_system_score_gemma":0.0001379598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000415221,"about_ca_topic_score_gemma":0.000473547,"domain_scores_codex":[0.9999191,0.00001441828,0.000009187973,0.00001650034,0.00001754058,0.00002331154],"domain_scores_gemma":[0.9999038,0.00001694646,0.0000227408,0.00001113082,0.00001492108,0.00003043752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002109248,0.000009592138,0.0001140241,0.00001762208,0.000002822265,0.00001820693,0.00000501449,0.00001167389,0.999217,0.00001154244,0.000007516874,0.0003739714],"study_design_scores_gemma":[0.0000072948,0.0001723271,0.002219964,0.000004532534,0.000009775197,0.00004140135,0.00001429663,0.0001045452,0.9968573,0.00001637106,0.0005508587,0.000001431328],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943064,0.002194479,0.001742282,0.00006213575,0.00003058019,0.00002006439,0.0005204652,0.00005340252,0.001070216],"genre_scores_gemma":[0.9928845,0.001737587,0.001576563,0.000079527,0.00001525454,0.00004623995,0.0008463878,0.0000214646,0.002792437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001590993,"threshold_uncertainty_score":0.005322397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01498455265168371,"score_gpt":0.2234543108039984,"score_spread":0.2084697581523147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}