{"id":"W3184513615","doi":"10.3390/biom11071044","title":"Enzymatic and Chemical Syntheses of Vacor Analogs of Nicotinamide Riboside, NMN and NAD","year":2021,"lang":"en","type":"article","venue":"Biomolecules","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Norges Forskningsråd; European Commission; Ministère de l'Économie, de la Science et de l'Innovation - Québec","keywords":"NAD+ kinase; Nicotinamide mononucleotide; Nicotinamide adenine dinucleotide; Riboside; Nicotinamide phosphoribosyltransferase; Nicotinamide; Chemistry; Biochemistry; Enzyme; Nucleotide salvage; Moiety; Niacinamide; Glycerol-3-phosphate dehydrogenase; Cofactor; Stereochemistry; Nucleotide","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001879963,0.0003641513,0.0002002287,0.0003371459,0.0002243745,0.0001780759,0.000365536,0.0002690907,0.001322876],"category_scores_gemma":[0.0002149451,0.0001340909,0.0002360973,0.0004087003,0.0001449268,0.0002282032,0.0002135941,0.0004665162,0.0005942137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003164264,"about_ca_system_score_gemma":0.0004012845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005568914,"about_ca_topic_score_gemma":0.001170271,"domain_scores_codex":[0.9998148,0.00003402516,0.00002142557,0.00004055396,0.00006152599,0.00002774011],"domain_scores_gemma":[0.9998952,0.00001150164,0.00002781591,0.00002484657,0.00002353126,0.00001718552],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009849488,0.00009031755,0.0002303712,0.0002939364,0.00001907976,0.0002869941,0.00008233841,0.001364002,0.9677609,0.003087868,0.000303766,0.02638195],"study_design_scores_gemma":[0.00001793799,0.0005187052,0.0006440872,0.00001613868,0.00002079561,0.0005488919,0.00003362769,0.000763352,0.9707419,0.0002835155,0.02639507,0.00001590558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7494037,0.01919317,0.1721427,0.0003368361,0.0003767751,0.001086275,0.003995777,0.0005843811,0.05288033],"genre_scores_gemma":[0.9052696,0.007362772,0.0756487,0.0001059785,0.00005720395,0.0003144962,0.002848774,0.00008135875,0.008311125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001322876,"threshold_uncertainty_score":0.004425406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01756444998252088,"score_gpt":0.2811610684200994,"score_spread":0.2635966184375785,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}