{"id":"W3184513615","doi":"10.3390/biom11071044","title":"Enzymatic and Chemical Syntheses of Vacor Analogs of Nicotinamide Riboside, NMN and NAD","year":2021,"lang":"en","type":"article","venue":"Biomolecules","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Norges Forskningsråd; European Commission; Ministère de l'Économie, de la Science et de l'Innovation - Québec","keywords":"NAD+ kinase; Nicotinamide mononucleotide; Nicotinamide adenine dinucleotide; Riboside; Nicotinamide phosphoribosyltransferase; Nicotinamide; Chemistry; Biochemistry; Enzyme; Nucleotide salvage; Moiety; Niacinamide; Glycerol-3-phosphate dehydrogenase; Cofactor; Stereochemistry; Nucleotide","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007587457,0.00008648341,0.0002796302,0.00005700971,0.00001295599,0.000004992462,0.00003047711,0.00005594558,0.00006852943],"category_scores_gemma":[0.0002458818,0.00007729398,0.00004318997,0.000133622,0.000295459,0.0000226935,0.00003576369,0.00004463131,0.000001074603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001480378,"about_ca_system_score_gemma":0.00006731221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003637873,"about_ca_topic_score_gemma":0.000005969619,"domain_scores_codex":[0.9993231,0.00003387439,0.000238684,0.0001636393,0.0001408794,0.00009987072],"domain_scores_gemma":[0.9994098,0.0001616327,0.00009068548,0.0001689445,0.00009982387,0.00006913384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006610293,0.00008476848,0.003489526,0.0003905513,0.00006678999,0.00002193919,0.0001278925,8.09507e-8,0.9912316,0.001093693,0.0002421941,0.003184861],"study_design_scores_gemma":[0.0006709904,0.00008964573,0.006430108,0.0005216598,0.0000650051,0.0001431722,0.0001791997,0.00004022464,0.9910225,0.0004753981,0.0002926345,0.00006941242],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917125,0.006063121,0.0002878151,0.0007514601,0.00002711953,0.00009117406,0.00003237143,0.00001355128,0.001020908],"genre_scores_gemma":[0.9964902,0.000452356,0.002781489,0.0001712826,0.00002425297,0.000006362449,0.000007968908,0.00001083232,0.0000551995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005610765,"threshold_uncertainty_score":0.3151957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01756444998252088,"score_gpt":0.2811610684200994,"score_spread":0.2635966184375785,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}