{"id":"W3184532391","doi":"10.1152/physrev.00033.2020","title":"Calcium-release channels: structure and function of IP<sub>3</sub> receptors and ryanodine receptors","year":2021,"lang":"en","type":"review","venue":"Physiological Reviews","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":226,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC; Government of Canada","keywords":"Ryanodine receptor; Receptor; Calcium; Biophysics; Chemistry; Cell biology; Calcium signaling; Biology; Endocrinology; Neuroscience; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003190566,0.001041151,0.0009938357,0.0006831283,0.0002533324,0.0009343259,0.0007022353,0.00111171,0.002169856],"category_scores_gemma":[0.0003480339,0.0003221249,0.0003434535,0.001094814,0.0006272834,0.001719555,0.00050312,0.001409204,0.003296199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007980582,"about_ca_system_score_gemma":0.0005289599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000576024,"about_ca_topic_score_gemma":0.0003993351,"domain_scores_codex":[0.9998425,0.00002037745,0.0000151127,0.00004803256,0.0000506197,0.00002323778],"domain_scores_gemma":[0.9998989,0.00002791673,0.0000218925,0.000004579082,0.00003139179,0.00001524548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000444609,0.0001188738,0.0002680112,0.0156517,0.00006919348,0.0004817324,0.0003325518,0.002323292,0.1382999,0.02533744,0.0499332,0.7667397],"study_design_scores_gemma":[0.00001905179,0.0001924499,0.001626121,0.001001019,0.00006320322,0.0008443781,0.0001053764,0.0004848245,0.01196652,0.009133951,0.9745181,0.00004500561],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001050447,0.994829,0.001181845,0.0004696741,0.0004165612,0.000007363285,0.00004597289,0.00004667732,0.001952466],"genre_scores_gemma":[0.005616574,0.9892748,0.001082456,0.0002740328,0.0004287016,0.00001578101,0.0001028198,0.00001690546,0.003187942],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002169856,"threshold_uncertainty_score":0.007258892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05934497270290626,"score_gpt":0.3065549274979132,"score_spread":0.247209954795007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}