{"id":"W3184560250","doi":"10.3389/fncel.2021.703951","title":"Single Cell Transcriptomics of Ependymal Cells Across Age, Region and Species Reveals Cilia-Related and Metal Ion Regulatory Roles as Major Conserved Ependymal Cell Functions","year":2021,"lang":"en","type":"article","venue":"Frontiers in Cellular Neuroscience","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Universities Space Research Association; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Ependymal Cell; Cilium; Biology; Cerebrospinal fluid; Cell; Neuroscience; Lateral ventricles; Motile cilium; Cell biology; Central nervous system; Pathology; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000440257,0.0002180962,0.0006167355,0.0006279892,0.0005129327,0.0007963094,0.000313965,0.0004495986,0.001095652],"category_scores_gemma":[0.0008027286,0.0001673199,0.0004776812,0.0008709249,0.0004705563,0.0004768819,0.0006491072,0.0006157115,0.0007385985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002377103,"about_ca_system_score_gemma":0.0003670702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001721113,"about_ca_topic_score_gemma":0.004677854,"domain_scores_codex":[0.9996248,0.00002040428,0.00002192739,0.0002010949,0.00007947025,0.00005226365],"domain_scores_gemma":[0.9996204,0.0001233628,0.00006813867,0.00005594648,0.00009274648,0.0000393106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002416493,0.00002353173,0.04547555,0.0005449179,0.0002218083,0.0003435699,0.000463115,0.0008737386,0.9193326,0.001002253,0.002015891,0.02946131],"study_design_scores_gemma":[0.00002566443,0.0002008686,0.7773343,0.000169217,0.000400945,0.001312072,0.0009751986,0.007540191,0.161589,0.003935568,0.04640969,0.0001074471],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8935788,0.006785853,0.04974368,0.000436574,0.0002322145,0.00006538715,0.04344937,0.0006115848,0.005096466],"genre_scores_gemma":[0.9218061,0.003628402,0.02999548,0.0008202853,0.00009840311,0.0003210461,0.03910179,0.0003730716,0.003855551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001721113,"threshold_uncertainty_score":0.003665328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01512367951683105,"score_gpt":0.2044013709112345,"score_spread":0.1892776913944034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}