{"id":"W3184579517","doi":"10.1371/journal.ppat.1009682","title":"Development of emodepside as a possible adulticidal treatment for human onchocerciasis—The fruit of a successful industrial–academic collaboration","year":2021,"lang":"en","type":"review","venue":"PLoS Pathogens","topic":"Parasitic Diseases Research and Treatment","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Bayer; Bill and Melinda Gates Foundation","keywords":"Onchocerciasis; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002359396,0.000469404,0.002263657,0.000274879,0.0001586901,0.00002213881,0.0002121786,0.0003934208,0.0001408678],"category_scores_gemma":[0.0004827912,0.0003015807,0.0006788896,0.0006054375,0.00009861148,0.00004302763,0.00006902756,0.0002502229,0.00002187371],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009048979,"about_ca_system_score_gemma":0.007479594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004510667,"about_ca_topic_score_gemma":0.0000625528,"domain_scores_codex":[0.9968653,0.0002182552,0.001245295,0.0005071723,0.0007194427,0.0004445621],"domain_scores_gemma":[0.9975871,0.0003661773,0.0006332591,0.0005659738,0.0005308847,0.000316607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003051114,0.003284307,0.001380218,0.01354036,0.006521613,0.0001877839,0.001408735,0.000001335983,0.000519889,0.0002825732,0.0002240789,0.972344],"study_design_scores_gemma":[0.01968355,0.006637619,0.0008511973,0.1027269,0.0534178,0.0001756888,0.003021045,0.00005926437,0.02274141,0.0001706075,0.7887934,0.001721462],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.06460656,0.9269823,0.00001532923,0.00006469657,0.00006294369,0.006231469,0.001582261,0.0000258701,0.0004284949],"genre_scores_gemma":[0.007301003,0.983601,0.001575237,0.00002103317,0.0002594945,0.003425326,0.002850354,0.00009532514,0.0008712652],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9706225,"threshold_uncertainty_score":0.9999436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.211447471092209,"score_gpt":0.4521781374696034,"score_spread":0.2407306663773944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}