{"id":"W3184605030","doi":"10.1016/j.neulet.2021.136117","title":"CLN3, at the crossroads of endocytic trafficking","year":2021,"lang":"en","type":"article","venue":"Neuroscience Letters","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Institut National de la Recherche Scientifique; Université du Québec à Montréal","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research","keywords":"Batten disease; Endocytic cycle; Biology; Endosome; Endocytosis; Cell biology; Neurodegeneration; Transmembrane protein; Autophagy; Loss function; Neuronal ceroid lipofuscinosis; Neuroscience; Genetics; Phenotype; Disease; Gene; Receptor; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005344707,0.0003530835,0.0003609158,0.0004742117,0.001166909,0.002747591,0.0008315726,0.002843512,0.003391317],"category_scores_gemma":[0.000839128,0.0002306633,0.0002628777,0.0003574438,0.001130872,0.001833024,0.001261586,0.001903979,0.00159109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002178256,"about_ca_system_score_gemma":0.001535936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003397244,"about_ca_topic_score_gemma":0.003641595,"domain_scores_codex":[0.9996892,0.00003100905,0.00002217092,0.00007152268,0.0001015903,0.00008455147],"domain_scores_gemma":[0.9997157,0.00003401915,0.00004794757,0.00001878086,0.00008060366,0.0001029646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002693773,0.00007626045,0.008551226,0.001083097,0.00008828584,0.01071236,0.0005880687,0.001434799,0.6893561,0.1343198,0.0693526,0.08174352],"study_design_scores_gemma":[0.0002289555,0.0002646563,0.01794023,0.0007561375,0.00008227296,0.01655386,0.002232049,0.008037287,0.3239747,0.09212711,0.5376537,0.0001491049],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4423222,0.2024415,0.03363339,0.175172,0.014006,0.0001239306,0.002752201,0.001544928,0.1280039],"genre_scores_gemma":[0.9334207,0.03017495,0.005864743,0.007435659,0.00118979,0.00003792162,0.0007614989,0.0001114495,0.0210032],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003397244,"threshold_uncertainty_score":0.01580441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03523633615062559,"score_gpt":0.3149040566401134,"score_spread":0.2796677204894878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}