{"id":"W3184605030","doi":"10.1016/j.neulet.2021.136117","title":"CLN3, at the crossroads of endocytic trafficking","year":2021,"lang":"en","type":"article","venue":"Neuroscience Letters","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Institut National de la Recherche Scientifique; Université du Québec à Montréal","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research","keywords":"Batten disease; Endocytic cycle; Biology; Endosome; Endocytosis; Cell biology; Neurodegeneration; Transmembrane protein; Autophagy; Loss function; Neuronal ceroid lipofuscinosis; Neuroscience; Genetics; Phenotype; Disease; Gene; Receptor; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001695315,0.00008607873,0.0001452821,0.0000500371,0.0001972351,0.00003936533,0.0002317083,0.00002400838,0.0001510778],"category_scores_gemma":[0.0006065606,0.00005947658,0.00009604412,0.0006462917,0.00064865,0.00007629846,0.0001245845,0.0002088747,0.00002590182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008968909,"about_ca_system_score_gemma":0.0001262824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001271154,"about_ca_topic_score_gemma":0.00001066632,"domain_scores_codex":[0.9984083,0.00007148099,0.0001608022,0.0003233932,0.000683866,0.0003522187],"domain_scores_gemma":[0.9992828,0.0001056799,0.000045909,0.0004213576,0.00006080441,0.00008340735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002338847,0.00004849267,0.0307103,0.00002730736,0.000002187987,0.0003905949,0.000300114,0.0001532617,0.9650407,0.00002118887,0.001970912,0.001311541],"study_design_scores_gemma":[0.001983844,0.0002478244,0.2775535,0.00006147821,0.00004429394,0.001267503,0.0005075244,0.001869442,0.6862871,0.000009864973,0.02993525,0.0002323548],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9776146,0.0001227674,0.00008885551,0.02063182,0.0002080633,0.0001537126,0.00000216772,0.0000241547,0.001153883],"genre_scores_gemma":[0.9800749,0.00001464283,0.00004244161,0.01886682,0.00004177225,0.000007081752,0.000001753152,0.00001155079,0.0009390736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2787536,"threshold_uncertainty_score":0.2425385,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03523633615062559,"score_gpt":0.3149040566401134,"score_spread":0.2796677204894878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}