{"id":"W3184613988","doi":"10.1093/jnci/djab147","title":"Breast and Prostate Cancer Risks for Male<i>BRCA1</i>and<i>BRCA2</i>Pathogenic Variant Carriers Using Polygenic Risk Scores","year":2021,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; McGill University; Centre hospitalier universitaire de Québec; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Jonsson Comprehensive Cancer Center; National Center for Advancing Translational Sciences; National Cancer Institute; Medical Research Council; Canadian Institutes of Health Research; University of California, Los Angeles; National Institutes of Health; Kerry Group Kuok Foundation; Freistaat Sachsen; Centro de Investigación Biomédica en Red de Cáncer; Fox Chase Cancer Center; Ministero dello Sviluppo Economico; Hospices Civils de Lyon; Deutsche Krebshilfe; Associazione Italiana per la Ricerca sul Cancro; European Regional Development Fund; Centre National de la Recherche Scientifique; Lietuvos Mokslo Taryba; University of California, San Francisco; Universiteit Gent; Ovarian Cancer Research Fund; Ministerio de Economía y Competitividad; Landspítali Háskólasjúkrahús; Hungarian Scientific Research Fund; Korea Health Industry Development Institute; KWF Kankerbestrijding; Universitair Ziekenhuis Gent; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Institut National de la Santé et de la Recherche Médicale; Ministero della Salute; Generalitat de Catalunya; Russian Foundation for Basic Research; Cancer Association of South Africa; Ministerstvo Školství, Mládeže a Tělovýchovy; National Breast Cancer Foundation; European Commission; Nemzeti Kutatási Fejlesztési és Innovációs Hivatal; National Institute for Health and Care Research; Cancer Research UK; Government of Canada; Ministero dell’Istruzione, dell’Università e della Ricerca; NRG Oncology; Memorial Sloan-Kettering Cancer Center; Fondation du cancer du sein du Québec; Cedars-Sinai Medical Center; Israel Cancer Association; Institut Gustave-Roussy; University of Pennsylvania; Fundación Mutua Madrileña; Ministère du Développement Économique, de l’Innovation et de l’Exportation; Breast Cancer Research Foundation; Univerzita Karlova v Praze; McGill University; National Institute of General Medical Sciences; Institut National Du Cancer; Dipartimenti di Eccellenza; Genome Canada; Unicancer; Clalit Health Services; Deutsches Krebsforschungszentrum; Kræftens Bekæmpelse; NIH Office of the Director; Ministério da Ciência, Tecnologia e Inovação; Kansas Bioscience Authority; Dr. Ralph and Marian Falk Medical Research Trust; Susan G. Komen for the Cure; Georgetown University; Fonds Wetenschappelijk Onderzoek; Cancer Center, University of Kansas; Cancerfonden; Cancer Australia; National Health and Medical Research Council; Jewish General Hospital; Fisher Center for Alzheimer's Research Foundation; Instituto de Salud Carlos III; Ohio State University; Beth Israel Deaconess Medical Center; Istituto Oncologico Veneto; Royal Marsden NHS Foundation Trust; European Social Fund; University of Chicago","keywords":"Oncology; Medicine; Prostate cancer; Breast cancer; Lifetime risk; Internal medicine; Prostate; Polygenic risk score; Cancer; Gynecology; Biology; Genetics; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001509468,0.0005498393,0.0002237942,0.001279456,0.0002062146,0.0004751087,0.0002938706,0.0003202049,0.001585225],"category_scores_gemma":[0.003179041,0.0001769232,0.0009012007,0.0008603348,0.0002364501,0.0002110957,0.0004250869,0.000452815,0.0001600627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002325784,"about_ca_system_score_gemma":0.0002111786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005340955,"about_ca_topic_score_gemma":0.005165858,"domain_scores_codex":[0.9993345,0.0003102554,0.00004365111,0.0001538884,0.0001103806,0.00004729191],"domain_scores_gemma":[0.9979466,0.0006812815,0.0008882287,0.0001998873,0.0001304433,0.000153658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001368007,0.00001389976,0.9954636,0.000007252866,0.0002487172,0.00003011053,0.00002512896,0.0003180025,0.0003445272,0.00003839914,0.00008294009,0.003290581],"study_design_scores_gemma":[0.00001255861,0.0001511943,0.9971078,0.000005710188,0.000203001,0.0003663034,0.00002305516,0.001541636,0.0002612857,0.00008790485,0.0002338233,0.00000571833],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971138,0.0002628418,0.001451732,0.00004576007,0.00000330179,0.00002076993,0.000605202,0.00002048134,0.000476018],"genre_scores_gemma":[0.9978774,0.0001022001,0.001179441,0.0000123966,0.000007893161,0.00001256528,0.000655616,0.000004000571,0.0001486112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005340955,"threshold_uncertainty_score":0.01061976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0364730212184901,"score_gpt":0.3315402880219236,"score_spread":0.2950672668034335,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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