{"id":"W3184690681","doi":"10.4049/immunohorizons.2100062","title":"Monoclonal Antibody Targeting the CD154 Cleavage Site Inhibits CD40-Dependent and -Independent Cleavage of CD154 from the Cell Surface","year":2021,"lang":"en","type":"article","venue":"ImmunoHorizons","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"CD154; Cleavage (geology); Monoclonal antibody; CD40; Chemistry; Cell biology; Antibody; Biology; Immunology; Biochemistry; Cytotoxic T cell; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006010022,0.0003056276,0.0003728106,0.00004203992,0.0007097621,0.00009133352,0.0003531504,0.0002747065,0.0009809945],"category_scores_gemma":[0.0001392524,0.0002077804,0.0002017673,0.000217233,0.0002693356,0.0002085931,0.0004306121,0.0009748344,0.0006622886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005665911,"about_ca_system_score_gemma":0.000107695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001111327,"about_ca_topic_score_gemma":0.00008914038,"domain_scores_codex":[0.9976164,0.0007005496,0.0006309491,0.0004793326,0.0001348625,0.0004379655],"domain_scores_gemma":[0.9980503,0.0007360851,0.0003454517,0.0006681003,0.0001734214,0.00002666449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002013246,0.0001653019,0.00317915,0.00001046758,0.0002385176,0.00001056401,0.001530829,0.00002407422,0.9786397,0.0001342442,0.01507422,0.0007916191],"study_design_scores_gemma":[0.001195524,0.0001588018,0.01316159,0.00005093863,0.000125318,0.00008044484,0.005326721,0.00002036155,0.9274999,0.00003786111,0.05210197,0.0002405011],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9667458,0.02216244,0.0005624196,0.0009242087,0.003837287,0.0003050361,0.00009350756,0.00006449333,0.005304804],"genre_scores_gemma":[0.988663,0.001404545,0.00007377887,0.0002970809,0.00009266893,0.000008635027,0.0005273639,0.00003675165,0.008896244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05113972,"threshold_uncertainty_score":0.9999322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007936370413627878,"score_gpt":0.2284532242392152,"score_spread":0.2205168538255873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}