{"id":"W3184690681","doi":"10.4049/immunohorizons.2100062","title":"Monoclonal Antibody Targeting the CD154 Cleavage Site Inhibits CD40-Dependent and -Independent Cleavage of CD154 from the Cell Surface","year":2021,"lang":"en","type":"article","venue":"ImmunoHorizons","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"CD154; Cleavage (geology); Monoclonal antibody; CD40; Chemistry; Cell biology; Antibody; Biology; Immunology; Biochemistry; Cytotoxic T cell; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002071741,0.0006254373,0.0003888456,0.0003679961,0.0001097483,0.0001974605,0.000358904,0.0004094506,0.0009021625],"category_scores_gemma":[0.0001483356,0.0001896062,0.0003069443,0.0001856331,0.0001353617,0.0001144139,0.000151548,0.0006760464,0.0003308689],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002952066,"about_ca_system_score_gemma":0.0002184486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002745937,"about_ca_topic_score_gemma":0.0004567522,"domain_scores_codex":[0.9997274,0.0000526539,0.00003070282,0.0000417037,0.000075606,0.00007186797],"domain_scores_gemma":[0.9999048,0.00001914166,0.00002719841,0.00001135767,0.00001859044,0.00001901288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007859116,0.0001394044,0.0001371767,0.00004800312,0.00000948263,0.00004226725,0.000006617292,0.00005938191,0.9969746,0.00004854298,0.00005657384,0.002399405],"study_design_scores_gemma":[0.0001225876,0.002961314,0.003178776,0.00001826702,0.00007175632,0.0009978376,0.000007901415,0.0008875903,0.9860805,0.00003003872,0.005637635,0.000005752795],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990957,0.002884452,0.003806107,0.00009641024,0.00005501405,0.0001084329,0.0001627001,0.0001073075,0.001822486],"genre_scores_gemma":[0.9891924,0.002029246,0.006012611,0.0001123181,0.00003567632,0.000142498,0.0006351628,0.00001202042,0.001828055],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009021625,"threshold_uncertainty_score":0.003018081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007936370413627878,"score_gpt":0.2284532242392152,"score_spread":0.2205168538255873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}