{"id":"W3184707783","doi":"10.3201/eid2708.203566","title":"Modeling Immune Evasion and Vaccine Limitations by Targeted Nasopharyngeal <i>Bordetella pertussis</i> Inoculation in Mice","year":2021,"lang":"en","type":"article","venue":"Emerging infectious diseases","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; National Institute on Deafness and Other Communication Disorders; National Institutes of Health; National Institute of General Medical Sciences; University of Georgia","keywords":"Bordetella pertussis; Immune system; Colonization; Immunity; Immunology; Biology; Pneumonia; Respiratory tract; Immunization; Evasion (ethics); Virology; Microbiology; Medicine; Respiratory system; Bacteria; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002540135,0.0005366763,0.0003888567,0.0003520133,0.000123359,0.0005647275,0.0005389886,0.0006538851,0.0008309848],"category_scores_gemma":[0.0002445434,0.0002939577,0.0003935203,0.0001818074,0.0002902881,0.0004445395,0.0002811883,0.0009190714,0.0002150277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000511804,"about_ca_system_score_gemma":0.0004212077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001968944,"about_ca_topic_score_gemma":0.001563609,"domain_scores_codex":[0.9998369,0.00002496397,0.000008137251,0.00003950776,0.00002759228,0.00006291931],"domain_scores_gemma":[0.999848,0.0000388175,0.0000639136,0.00001215404,0.00001256309,0.00002461052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004582527,0.0004249158,0.002591233,0.0001884881,0.00005006269,0.0001723707,0.00005550331,0.08563296,0.902392,0.003103583,0.0002721258,0.00465848],"study_design_scores_gemma":[0.0001349062,0.002646984,0.005225917,0.00005804811,0.0001568756,0.0002487099,0.0001145943,0.5338772,0.450541,0.002346105,0.004616784,0.00003292485],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.969343,0.001163198,0.02520437,0.000174084,0.00003619097,0.00008832198,0.0006112636,0.0001347344,0.003244926],"genre_scores_gemma":[0.9866254,0.001446945,0.009914734,0.0000976875,0.00001100315,0.0001593579,0.0003031771,0.00005255963,0.001389066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001968944,"threshold_uncertainty_score":0.003914893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01089325494308313,"score_gpt":0.2357992728791004,"score_spread":0.2249060179360173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}