{"id":"W3184802087","doi":"10.1093/jncics/pkab066","title":"Cancer Antigen 15-3/Mucin 1 Levels in CCTG MA.32: A Breast Cancer Randomized Trial of Metformin vs Placebo","year":2021,"lang":"en","type":"article","venue":"JNCI Cancer Spectrum","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Université Laval; Juravinski Cancer Centre; University of British Columbia; Roche (Canada); BC Cancer Agency; McMaster University; Queen's University; Princess Margaret Cancer Centre; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Statistics Canada; University of Toronto","funders":"National Cancer Institute; Canadian Cancer Society Research Institute","keywords":"Metformin; Medicine; Placebo; Breast cancer; Internal medicine; Cancer; Oncology; Mucin; Randomized controlled trial; Antigen; Endocrinology; Immunology; Pathology; Insulin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007536183,0.0004427294,0.00134443,0.0001389192,0.00007272893,0.00004262073,0.0003847331,0.000322948,0.003277398],"category_scores_gemma":[0.0001131536,0.0004021352,0.0004748439,0.0004676296,0.0001991013,0.00002126552,0.0001698616,0.0002741049,0.000007154315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002044267,"about_ca_system_score_gemma":0.001872555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005685673,"about_ca_topic_score_gemma":0.01451813,"domain_scores_codex":[0.9967372,0.0003317944,0.0008650188,0.0008401367,0.000451758,0.0007740621],"domain_scores_gemma":[0.9984775,0.00005671429,0.0004239719,0.0006613566,0.0001986682,0.0001818273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.7263896,0.0007179449,0.0066432,0.0004053844,0.002003113,0.00005149935,0.0007992887,0.0007848584,0.1225072,0.0006884907,0.01283875,0.1261706],"study_design_scores_gemma":[0.4284784,0.0001029187,0.002233125,0.0001744417,0.0002112224,0.00000957518,0.00008759383,0.00009538495,0.4925552,0.0003254178,0.07512249,0.0006042199],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7670481,0.2271737,0.00009224507,0.0007105565,0.002180697,0.0009542047,0.001013453,0.00001755179,0.000809529],"genre_scores_gemma":[0.7700282,0.2221474,0.0001463025,0.0009028346,0.002542944,0.001374924,0.00006824816,0.00008383876,0.002705306],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.370048,"threshold_uncertainty_score":0.9998431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01249851219347477,"score_gpt":0.2860770298812272,"score_spread":0.2735785176877524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}