{"id":"W3184839936","doi":"10.1016/j.xcrm.2021.100344","title":"A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope","year":2021,"lang":"en","type":"article","venue":"Cell Reports Medicine","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"National Cancer Institute; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; National Institute of Mental Health; Canada Research Chairs; National Institutes of Health; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Evans Medical Foundation; Alex's Lemonade Stand Foundation for Childhood Cancer; Office of Science; National Institute on Drug Abuse; American Association for Cancer Research; St. Baldrick's Foundation; Hyundai Hope On Wheels; Damon Runyon Cancer Research Foundation; Argonne National Laboratory; U.S. Department of Energy","keywords":"Neuroblastoma; Epitope; Cancer research; Antibody-drug conjugate; Antibody; Biology; In vivo; Chemistry; Monoclonal antibody; Molecular biology; Cell culture; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002071281,0.0003088788,0.0002735839,0.000148963,0.0001838638,0.0003022426,0.0002314689,0.0003951881,0.001890086],"category_scores_gemma":[0.000218246,0.000118144,0.0001533062,0.0001312921,0.0002877646,0.000252546,0.0001626976,0.0006940634,0.0002827761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005227425,"about_ca_system_score_gemma":0.0003598939,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00206124,"about_ca_topic_score_gemma":0.003066102,"domain_scores_codex":[0.999873,0.00002826652,0.000006174491,0.00002129096,0.0000382279,0.00003293277],"domain_scores_gemma":[0.9999335,0.00001796883,0.00001160524,0.000008761082,0.00001239762,0.00001581444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004213777,0.00021956,0.0003322334,0.00005904628,0.00001851154,0.0001427714,0.00002279474,0.0004127676,0.9918521,0.0003371314,0.0004314134,0.005750266],"study_design_scores_gemma":[0.0003043565,0.003624586,0.003690362,0.00001107875,0.00003299351,0.001125321,0.00001924357,0.002348698,0.9829795,0.00009991762,0.005752936,0.00001101466],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871962,0.001424546,0.004730779,0.0002980423,0.00005958577,0.0002285719,0.0003297857,0.0001243688,0.005608089],"genre_scores_gemma":[0.9957272,0.0004993056,0.001131055,0.0001009592,0.00001273153,0.00004550743,0.0004101731,0.00001502844,0.002058111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00206124,"threshold_uncertainty_score":0.00632298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01194836763785277,"score_gpt":0.2924480851286487,"score_spread":0.2804997174907959,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}