{"id":"W3184848011","doi":"10.1016/j.chembiol.2021.07.001","title":"Armeniaspirols inhibit the AAA+ proteases ClpXP and ClpYQ leading to cell division arrest in Gram-positive bacteria","year":2021,"lang":"en","type":"article","venue":"Cell chemical biology","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"FtsZ; Proteases; Bacteria; Bacillus subtilis; Cell division; Microbiology; Biology; Mode of action; Antibiotics; Bacterial cell structure; Mechanism of action; MreB; Cell biology; Cell; Biochemistry; In vitro; Enzyme; Genetics; Cytoskeleton","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001499244,0.0002247334,0.0002607382,0.00002868652,0.00006286943,0.00004228709,0.0002163599,0.0002972393,0.00002688977],"category_scores_gemma":[0.0001733511,0.0001751359,0.00006622874,0.0001322886,0.0002228343,0.000003754635,0.0004144247,0.0001910113,0.00002444325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002654696,"about_ca_system_score_gemma":0.00005795324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001271574,"about_ca_topic_score_gemma":0.00002122732,"domain_scores_codex":[0.9984466,0.0001459577,0.0002919839,0.0006525661,0.00006009393,0.0004027898],"domain_scores_gemma":[0.9992968,0.00007524474,0.0000830922,0.0003622441,0.00006089082,0.0001216696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001042398,0.00009229449,0.01552739,0.00003156616,0.00000865332,0.00001331487,0.00005755614,9.425027e-7,0.9830338,0.00003509644,0.0002702953,0.0008247956],"study_design_scores_gemma":[0.0004263517,0.0001505786,0.006820827,0.00004039985,0.000009722147,0.000009442087,0.00008161964,0.000003429972,0.9872628,0.0001494457,0.004816231,0.0002291705],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997187,0.0006053823,0.0001968604,0.0004220573,0.0001476639,0.0003417328,0.00003575023,0.00000981835,0.001053746],"genre_scores_gemma":[0.9976926,0.0001098597,0.0008305999,0.0006187159,0.000171008,0.00002654444,0.00022111,0.00002270799,0.0003068675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008706563,"threshold_uncertainty_score":0.7141833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007664466839129996,"score_gpt":0.24397121832287,"score_spread":0.23630675148374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}