{"id":"W3184904656","doi":"10.1016/j.matbio.2021.07.001","title":"PAD2-mediated citrullination of Fibulin-5 promotes elastogenesis","year":2021,"lang":"en","type":"article","venue":"Matrix Biology","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Citrullination; Chemistry; In vitro; Cell biology; Tropoelastin; Citrulline; Biochemistry; Biology; Extracellular matrix; Amino acid; Arginine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002666822,0.0004787043,0.0002129708,0.0002184948,0.0002380514,0.000438639,0.000204069,0.000310708,0.003198408],"category_scores_gemma":[0.0001758594,0.000168985,0.0003623611,0.0001002283,0.0002859634,0.0002482145,0.0005410765,0.0006065313,0.0005832863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002786557,"about_ca_system_score_gemma":0.0002061568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003566659,"about_ca_topic_score_gemma":0.0007147531,"domain_scores_codex":[0.9998025,0.00003682156,0.00001383352,0.00005386815,0.00003354333,0.00005945547],"domain_scores_gemma":[0.9999025,0.00001540179,0.00002413159,0.00001821284,0.000009161904,0.00003068545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003549206,0.00004006485,0.0003954399,0.00005690124,0.00001205071,0.0001208538,0.00001083121,0.0001014459,0.9972101,0.000306092,0.0001090799,0.001282274],"study_design_scores_gemma":[0.00002425316,0.0001432872,0.005378104,0.00000558126,0.00001042031,0.0003435398,0.00002764892,0.0007602659,0.9905767,0.00009719832,0.002626849,0.00000617818],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862983,0.002698343,0.005956818,0.000279937,0.0002300958,0.00005169283,0.0004934541,0.0001412141,0.003850207],"genre_scores_gemma":[0.9939116,0.000303061,0.001696754,0.00009422412,0.00002167761,0.00002757903,0.0004604394,0.00001769507,0.003466983],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003198408,"threshold_uncertainty_score":0.01069975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01255027541043668,"score_gpt":0.3177927514627584,"score_spread":0.3052424760523217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}