{"id":"W3184904659","doi":"10.1158/0008-5472.can-21-0774","title":"Acquired <i>RAD51C</i> Promoter Methylation Loss Causes PARP Inhibitor Resistance in High-Grade Serous Ovarian Carcinoma","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Cancer Council Tasmania; Cancer Council Victoria; Cancer Council South Australia; Victorian Cancer Agency; Entertainment Industry Foundation; Stand Up To Cancer; Medical Research Council; Peter MacCallum Foundation; AstraZeneca Australia; Medical Research and Materiel Command; Eisai; Ovarian Cancer Research Fund; Cancer Australia; National Cancer Institute; Australian Cancer Research Foundation; Mayo Foundation for Medical Education and Research; State Government of Victoria; Australian Government; Cancer Council NSW; Ovarian Cancer Australia; National Breast Cancer Foundation; Clovis Oncology; Sierra Oncology; National Ovarian Cancer Coalition; American Association for Cancer Research; National Health and Medical Research Council; Cancer Research Institute; AstraZeneca; Ovarian Cancer Research Fund Alliance; National Institutes of Health","keywords":"Serous fluid; PARP inhibitor; Ovarian carcinoma; Methylation; Cancer research; Medicine; Ovarian cancer; Oncology; Internal medicine; Biology; Poly ADP ribose polymerase; Cancer; Gene; Genetics; Polymerase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008773134,0.00009458556,0.0001574342,0.0001979289,0.0001340741,0.0002028353,0.00007003734,0.0001368148,0.001142394],"category_scores_gemma":[0.0002012425,0.00008913472,0.0001278939,0.0001899547,0.0001566539,0.00007262779,0.0001627563,0.0002329334,0.0001429366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001462217,"about_ca_system_score_gemma":0.00007905191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008530547,"about_ca_topic_score_gemma":0.0008780299,"domain_scores_codex":[0.9999461,0.000009949855,0.000005660418,0.00001385316,0.00001212087,0.00001233104],"domain_scores_gemma":[0.9998564,0.00002704568,0.0000321656,0.00003026449,0.00001073418,0.00004341808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001957732,0.0001715684,0.5253231,0.00005799742,0.000075844,0.004300455,0.0003001462,0.000485288,0.4531417,0.0001612832,0.0003887934,0.01363604],"study_design_scores_gemma":[0.0000493971,0.0009892583,0.9477957,0.000004241369,0.00004470234,0.009684775,0.0002068439,0.001180365,0.03876115,0.0000844419,0.001194592,0.000004536901],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996401,0.00006047611,0.00006980795,0.000007786387,9.448663e-7,0.00000361195,0.00004336554,0.000006207352,0.000167686],"genre_scores_gemma":[0.9997779,0.00002116284,0.00003766731,0.000006207165,8.462011e-7,0.000001302359,0.0000684293,0.000001295138,0.00008537813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001142394,"threshold_uncertainty_score":0.003821671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09252431265740614,"score_gpt":0.4020122372412097,"score_spread":0.3094879245838036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}