{"id":"W3184943002","doi":"10.1016/j.isci.2021.102895","title":"Structural characterization of the mitochondrial Ca2+ uniporter provides insights into Ca2+ uptake and regulation","year":2021,"lang":"en","type":"review","venue":"iScience","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"Uniporter; Chemistry; Mitochondrion; Calcium; Biophysics; Biology; Biochemistry; Cytosol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000694011,0.0001842765,0.0003745422,0.00004938504,0.00012793,0.00003577666,0.0002253775,0.0002643992,0.00002102437],"category_scores_gemma":[0.0001243951,0.0001179464,0.0001363536,0.0002284474,0.0002293061,0.000009723447,0.0001687181,0.0001051476,0.000001440844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001227868,"about_ca_system_score_gemma":0.0003461814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001168185,"about_ca_topic_score_gemma":0.00006040501,"domain_scores_codex":[0.9987503,0.0001753535,0.0003523752,0.0004511455,0.0001506934,0.0001201064],"domain_scores_gemma":[0.9990973,0.00001109947,0.00033427,0.0004099605,0.0001041947,0.00004319036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001155592,0.00001142616,0.00003869265,0.0009581881,0.00002813922,0.000001944817,0.0002087941,0.000002098366,0.504257,0.0003376806,0.0001583762,0.4939861],"study_design_scores_gemma":[0.0001032544,0.00005776086,0.0003743348,0.0005433179,0.00007800706,0.0000526887,0.000008445964,0.00001456762,0.004474696,0.00003615446,0.9940906,0.000166135],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04132152,0.9541538,0.0006022706,0.00003632608,0.003049844,0.0006933072,0.00002519426,0.00000743901,0.0001102967],"genre_scores_gemma":[0.002146516,0.9933677,0.000507532,0.0001015098,0.0008756936,0.00004360835,0.0006047572,0.0000247454,0.002327917],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9939322,"threshold_uncertainty_score":0.4809713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02269717754922386,"score_gpt":0.2747902330906487,"score_spread":0.2520930555414248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}