{"id":"W3185001536","doi":"10.3390/cancers13143596","title":"The Next-Generation of Combination Cancer Immunotherapy: Epigenetic Immunomodulators Transmogrify Immune Training to Enhance Immunotherapy","year":2021,"lang":"en","type":"review","venue":"Cancers","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children; Ted Rogers Centre for Heart Research; Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada; Mitacs; Queen's University","keywords":"Immunotherapy; Immune system; Antigen; Cancer immunotherapy; Tumor microenvironment; Immunology; Cancer; Biology; Cancer research; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005529549,0.0006712506,0.0009904801,0.001380647,0.0001641383,0.0008062096,0.0007370776,0.001046053,0.003763522],"category_scores_gemma":[0.0005547376,0.000188705,0.0006719275,0.0008528872,0.0003640825,0.001197651,0.0006066643,0.002168804,0.001678434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000535499,"about_ca_system_score_gemma":0.0006080951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004262845,"about_ca_topic_score_gemma":0.001011453,"domain_scores_codex":[0.9998193,0.00004587758,0.00001679838,0.00002882424,0.00006467728,0.00002450417],"domain_scores_gemma":[0.9998098,0.00009436155,0.00002355215,0.000008102293,0.00004561191,0.00001851608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001010102,0.000122518,0.0001588341,0.0103091,0.000122984,0.000137347,0.00003953322,0.0004194331,0.004212444,0.006024448,0.02810528,0.9502469],"study_design_scores_gemma":[0.00004085328,0.0001782417,0.0005750086,0.0023633,0.0001149524,0.00093754,0.00002958825,0.0002151995,0.001557014,0.002933458,0.9910376,0.00001734348],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000309221,0.9967846,0.0004449392,0.0004423968,0.0004275665,0.00001340186,0.00002489602,0.00001933415,0.001533661],"genre_scores_gemma":[0.002303007,0.9944,0.0006085735,0.0006711246,0.0002822574,0.00002479989,0.00006673843,0.000004646959,0.001638885],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003763522,"threshold_uncertainty_score":0.01259023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09459434894739228,"score_gpt":0.3696072190731526,"score_spread":0.2750128701257603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}