{"id":"W3185001536","doi":"10.3390/cancers13143596","title":"The Next-Generation of Combination Cancer Immunotherapy: Epigenetic Immunomodulators Transmogrify Immune Training to Enhance Immunotherapy","year":2021,"lang":"en","type":"review","venue":"Cancers","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children; Ted Rogers Centre for Heart Research; Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada; Mitacs; Queen's University","keywords":"Immunotherapy; Immune system; Antigen; Cancer immunotherapy; Tumor microenvironment; Immunology; Cancer; Biology; Cancer research; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009211929,0.0008790267,0.002848111,0.0003433328,0.0003852091,0.0001537134,0.0006634887,0.0005456043,0.0002960179],"category_scores_gemma":[0.00004893154,0.0006617563,0.001663158,0.001554109,0.0003491637,0.0001463435,0.00003973321,0.0007128177,0.000007006028],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003523947,"about_ca_system_score_gemma":0.005961191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001198961,"about_ca_topic_score_gemma":0.0001893914,"domain_scores_codex":[0.9952575,0.0003889383,0.002026887,0.0008660808,0.0007015273,0.0007590693],"domain_scores_gemma":[0.9967525,0.0002660772,0.001055802,0.001376085,0.0003969647,0.0001525555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003912681,0.00004307472,0.000002364988,0.001442338,0.002278498,0.000005428853,0.001404663,0.00003400722,0.01934489,0.00007146713,0.0003906735,0.9745913],"study_design_scores_gemma":[0.001323037,0.000520767,0.00005591133,0.01342026,0.0006621284,0.00003434685,0.0003545395,0.00003862345,0.004621616,0.000007333153,0.9782685,0.0006929584],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002010564,0.9914268,0.0003540321,0.0004088986,0.002699581,0.002780827,0.00008796071,0.0001022091,0.0001291826],"genre_scores_gemma":[0.003227431,0.9926512,0.0002157829,0.0003758958,0.0004769551,0.00148031,0.0002498015,0.0003201773,0.001002436],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9778778,"threshold_uncertainty_score":0.9996741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09459434894739228,"score_gpt":0.3696072190731526,"score_spread":0.2750128701257603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}