{"id":"W3185064872","doi":"10.1002/cam4.4029","title":"Fragility of randomized trials supporting cancer drug approvals stratified by approval pathway and review designations","year":2021,"lang":"en","type":"article","venue":"Cancer Medicine","topic":"Health Systems, Economic Evaluations, Quality of Life","field":"Economics, Econometrics and Finance","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"National Breast Cancer Foundation","keywords":"Medicine; Randomization; Fragility; Logistic regression; Clinical trial; Internal medicine; Food and drug administration; Randomized controlled trial; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.424777,0.001472723,0.005569148,0.0153943,0.001445804,0.00644426,0.002764991,0.002463306,0.007568884],"category_scores_gemma":[0.7289858,0.001290194,0.01475499,0.01426427,0.003577,0.007744573,0.004321767,0.00266969,0.0005250798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004029694,"about_ca_system_score_gemma":0.004188993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007250728,"about_ca_topic_score_gemma":0.001485606,"domain_scores_codex":[0.4560942,0.3178323,0.1573068,0.02784942,0.03594229,0.004974967],"domain_scores_gemma":[0.08046988,0.7209008,0.1607672,0.02415101,0.01217405,0.00153706],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.04996108,0.0001861552,0.4731615,0.1277765,0.205836,0.0009148872,0.001647543,0.003482069,0.001393239,0.006423811,0.005745075,0.1234722],"study_design_scores_gemma":[0.0111585,0.009440347,0.5786058,0.0777183,0.2253418,0.005177305,0.00138593,0.008207702,0.004219044,0.0292314,0.04899112,0.0005226417],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.3707953,0.5315359,0.03414232,0.00957249,0.001213435,0.01342259,0.02549977,0.0005849797,0.01323322],"genre_scores_gemma":[0.9636889,0.01217962,0.01071821,0.001667664,0.0004809638,0.006500498,0.004292548,0.0001158116,0.0003557454],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.575223,"threshold_uncertainty_score":0.7093524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4621303004139082,"score_gpt":0.5035654389088537,"score_spread":0.04143513849494557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}