{"id":"W3185064872","doi":"10.1002/cam4.4029","title":"Fragility of randomized trials supporting cancer drug approvals stratified by approval pathway and review designations","year":2021,"lang":"en","type":"article","venue":"Cancer Medicine","topic":"Health Systems, Economic Evaluations, Quality of Life","field":"Economics, Econometrics and Finance","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"National Breast Cancer Foundation","keywords":"Medicine; Randomization; Fragility; Logistic regression; Clinical trial; Internal medicine; Food and drug administration; Randomized controlled trial; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","insufficient_payload"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.07973783,0.0002369768,0.004892691,0.0001310486,0.0001233867,0.00002103356,0.0001711645,0.0001084951,0.00409322],"category_scores_gemma":[0.04528017,0.000226796,0.0002475575,0.0003203188,0.0003054665,0.0002180199,0.00003710443,0.0002032755,0.0000139586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002727171,"about_ca_system_score_gemma":0.0007452304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002511309,"about_ca_topic_score_gemma":0.0002303119,"domain_scores_codex":[0.9880803,0.002184873,0.008539598,0.0006737049,0.0001885305,0.0003329996],"domain_scores_gemma":[0.9874786,0.005518581,0.005958658,0.0004763497,0.0003440701,0.0002237133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001523079,0.0003786579,0.008586626,0.03331931,0.002112527,0.000006528373,0.01144226,0.0001043975,0.001549143,0.1050647,0.8112022,0.02471057],"study_design_scores_gemma":[0.3222101,0.0002977435,0.00390894,0.03520115,0.002343734,0.00003608585,0.01116675,0.01265167,0.006560852,0.1047046,0.4973606,0.003557734],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.0307513,0.7777479,0.01030384,0.1716378,0.001201975,0.003692907,0.001340737,0.00005001593,0.003273536],"genre_scores_gemma":[0.53701,0.3600778,0.00584357,0.07680289,0.002964373,0.006814269,0.0009863179,0.0001656791,0.009335143],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.5062587,"threshold_uncertainty_score":0.9968172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4621303004139082,"score_gpt":0.5035654389088537,"score_spread":0.04143513849494557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}