{"id":"W3185085250","doi":"10.1177/15353702211029284","title":"Proteinase 3 contributes to endothelial dysfunction in an experimental model of sepsis","year":2021,"lang":"en","type":"article","venue":"Experimental Biology and Medicine","topic":"Sepsis Diagnosis and Treatment","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Children’s Health Research Institute; Lawson Health Research Institute","funders":"","keywords":"Sepsis; Endothelial dysfunction; Vascular permeability; Umbilical vein; Inflammation; Proteases; Elastase; Immunology; Serine protease; Protease; Medicine; Endocrinology; Internal medicine; Chemistry; Enzyme; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005422294,0.0007251549,0.0007089583,0.0004790422,0.000259859,0.0004174739,0.0002613188,0.0005712669,0.002585465],"category_scores_gemma":[0.0003788007,0.000285312,0.0007778951,0.0003915971,0.0003986915,0.0003091278,0.0003224257,0.002107298,0.0003620372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003799331,"about_ca_system_score_gemma":0.0003393877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004562522,"about_ca_topic_score_gemma":0.0005104413,"domain_scores_codex":[0.9995632,0.0001301705,0.00004234232,0.00007328024,0.00009618407,0.00009490062],"domain_scores_gemma":[0.9996543,0.0000343206,0.0001131157,0.00005226404,0.00004032021,0.0001057599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002914318,0.0004181545,0.0005409825,0.0001776304,0.00003767822,0.0002374278,0.00003637956,0.00009291945,0.991323,0.0001539545,0.0001645719,0.003902961],"study_design_scores_gemma":[0.0003241228,0.007523183,0.03311346,0.00006276537,0.0001737797,0.001641683,0.0001382903,0.003933311,0.948873,0.0003600703,0.003820143,0.00003624864],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875677,0.003714317,0.005492166,0.0005649005,0.0002076045,0.0001021826,0.0005344707,0.0002079025,0.001608893],"genre_scores_gemma":[0.989454,0.002733728,0.003969572,0.0002912816,0.0000610284,0.0001908028,0.0005912033,0.00002817078,0.002680243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002585465,"threshold_uncertainty_score":0.00864929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06970568638389882,"score_gpt":0.3868929665334561,"score_spread":0.3171872801495573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}