{"id":"W3185085250","doi":"10.1177/15353702211029284","title":"Proteinase 3 contributes to endothelial dysfunction in an experimental model of sepsis","year":2021,"lang":"en","type":"article","venue":"Experimental Biology and Medicine","topic":"Sepsis Diagnosis and Treatment","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Children’s Health Research Institute; Lawson Health Research Institute","funders":"","keywords":"Sepsis; Endothelial dysfunction; Vascular permeability; Umbilical vein; Inflammation; Proteases; Elastase; Immunology; Serine protease; Protease; Medicine; Endocrinology; Internal medicine; Chemistry; Enzyme; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001038968,0.0001534451,0.0004420498,0.0001223531,0.00004187736,0.000002481851,0.0000309772,0.0001024576,0.0002427377],"category_scores_gemma":[0.00005826667,0.0001146902,0.00003806323,0.0001213755,0.0001703828,0.00004188019,0.00004386056,0.00007331881,0.000003801488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008688724,"about_ca_system_score_gemma":0.00004908143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001128931,"about_ca_topic_score_gemma":0.00002124333,"domain_scores_codex":[0.9990556,0.00005781444,0.0002819832,0.0003357811,0.00008463662,0.0001842195],"domain_scores_gemma":[0.9995328,0.00004072985,0.00004391679,0.0001773624,0.00005066068,0.0001545739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006443384,0.001397726,0.04040473,0.00001166269,0.00004931632,0.00003719923,0.001287928,0.000005627287,0.9537463,0.001539411,0.0001822604,0.0006935043],"study_design_scores_gemma":[0.006859,0.003359497,0.005568694,0.0001412347,0.00003834183,0.00002632675,0.003751265,0.0002461152,0.979536,0.0001040309,0.0002807754,0.00008874515],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882736,0.008658661,0.00004725696,0.001813543,0.0001607627,0.000523814,0.00001815664,0.00001721708,0.0004870501],"genre_scores_gemma":[0.9968092,0.00008407666,0.0005966173,0.001964015,0.00008347727,0.0002320961,0.0001145055,0.0000106197,0.0001053609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03483604,"threshold_uncertainty_score":0.467693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06970568638389882,"score_gpt":0.3868929665334561,"score_spread":0.3171872801495573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}