{"id":"W3185152062","doi":"10.1016/j.canlet.2021.07.039","title":"MICAL1 regulates actin cytoskeleton organization, directional cell migration and the growth of human breast cancer cells as orthotopic xenograft tumours","year":2021,"lang":"en","type":"article","venue":"Cancer Letters","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto Metropolitan University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Cancer Research UK","keywords":"Biology; Actin cytoskeleton; Gene expression; Cancer cell; Actin; Cancer research; Cell migration; Cell biology; Regulation of gene expression; Cytoskeleton; Breast cancer; Gene expression profiling; Cancer; Cell; Molecular biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000075437,0.0001400468,0.0001755996,0.00004403806,0.0002662902,0.00005148491,0.0001386751,0.00004077372,0.0003539898],"category_scores_gemma":[0.00004878589,0.0001117415,0.00005417798,0.0004684197,0.0002614433,0.0001478742,0.00004759853,0.0001483838,0.0000053892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005270446,"about_ca_system_score_gemma":0.00009168003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006174818,"about_ca_topic_score_gemma":0.0001147603,"domain_scores_codex":[0.998798,0.000151929,0.0002329768,0.0003696474,0.0002593541,0.0001881183],"domain_scores_gemma":[0.9993457,0.0001601579,0.0001754774,0.0001390797,0.0001255829,0.00005402093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003055965,0.00002175547,0.01612955,0.00003522493,0.000005777957,0.000007406873,0.0002791803,0.0001305291,0.9815633,0.0002131374,0.001494272,0.00008929456],"study_design_scores_gemma":[0.0005533803,0.000009878439,0.01984949,0.00004518909,0.00003251727,0.00002116851,0.0000312144,0.00003171402,0.9788752,0.00007202147,0.0003561121,0.0001221603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845179,0.0002189035,0.00005930179,0.01466847,0.0002488473,0.0001468634,0.00002802133,0.00003125465,0.00008048803],"genre_scores_gemma":[0.99206,0.0004737562,0.00001840264,0.006861102,0.0002147866,0.00002841141,0.000005443324,0.00002334173,0.0003147621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007807366,"threshold_uncertainty_score":0.4556686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0097747723785207,"score_gpt":0.2371415051071243,"score_spread":0.2273667327286036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}