{"id":"W3185166286","doi":"10.1016/j.cels.2021.06.003","title":"Seeds of their own destruction: Dominant-negative peptide screening yields functional insight and therapeutic leads","year":2021,"lang":"en","type":"article","venue":"Cell Systems","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"National Human Genome Research Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Peptide; Biology; Computational biology; Psychology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002716789,0.0004920477,0.0003317711,0.0002462481,0.0001559673,0.0005622341,0.0002177308,0.0004194283,0.001080727],"category_scores_gemma":[0.0002072729,0.0001943917,0.0001861649,0.000111826,0.0003177529,0.0002098073,0.0001663343,0.0007992176,0.0004644523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002361754,"about_ca_system_score_gemma":0.0001424832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001539313,"about_ca_topic_score_gemma":0.000261604,"domain_scores_codex":[0.9998593,0.00002549406,0.00001000347,0.00003074294,0.0000472647,0.00002711177],"domain_scores_gemma":[0.9998732,0.00005116972,0.00002394001,0.00001641586,0.00001324569,0.00002206086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006492937,0.00001403126,0.00002654854,0.00001436546,0.000002653602,0.00004109676,0.000008032619,0.0001447974,0.9980598,0.0003052615,0.00005484605,0.001263571],"study_design_scores_gemma":[0.00001665476,0.0001424111,0.0001252453,0.000002397658,0.00001095192,0.0001884677,0.00000692534,0.0008661452,0.9969196,0.0001510986,0.001567059,0.000003095972],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9493269,0.003060435,0.03838167,0.0004689021,0.0001230715,0.0001283516,0.0005959614,0.0005095187,0.007405205],"genre_scores_gemma":[0.9867406,0.001106227,0.008468145,0.00009070111,0.00001279523,0.00003753812,0.0003771173,0.00007495294,0.003091865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001080727,"threshold_uncertainty_score":0.003615379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01905907100968751,"score_gpt":0.21262735686927,"score_spread":0.1935682858595825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}