{"id":"W3185171385","doi":"10.1182/blood.2021011101","title":"Prognostic value of minimal residual disease negativity in myeloma: combined analysis of POLLUX, CASTOR, ALCYONE, and MAIA","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Calgary","funders":"National Cancer Institute","keywords":"Internal medicine; Medicine; Hazard ratio; Oncology; Multiple myeloma; Daratumumab; Proportional hazards model; Progression-free survival; Minimal residual disease; Confidence interval; Overall survival; Lenalidomide; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001352788,0.000118078,0.0005127753,0.000315899,0.00002325428,0.000006429373,0.00004497436,0.0000451453,0.00006529909],"category_scores_gemma":[0.0008820281,0.00010399,0.0001100837,0.0008721659,0.000118124,0.00004201198,0.00007740968,0.00008944741,0.000001344502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000196476,"about_ca_system_score_gemma":0.0002948199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000318317,"about_ca_topic_score_gemma":0.000309171,"domain_scores_codex":[0.9987135,0.0001416484,0.0002910135,0.0002640973,0.0003619779,0.0002277781],"domain_scores_gemma":[0.999009,0.0002423502,0.00008077678,0.0002883895,0.0001236451,0.000255816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007652842,0.003312694,0.9852631,0.0002403522,0.00173075,0.001460966,0.0001874923,0.000004572563,0.006234483,0.00009315185,0.00001070733,0.0006964206],"study_design_scores_gemma":[0.008033663,0.0003804095,0.9760093,0.0001006248,0.002903684,0.00001083383,0.00009656452,0.0006250362,0.01172974,0.00003784009,0.000003312263,0.00006897511],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980157,0.0009749745,0.000003671535,0.0002559266,0.000009890909,0.0003062037,0.000186942,0.000008323685,0.0002383643],"genre_scores_gemma":[0.9988043,0.00004945625,0.0007955035,0.0000139388,0.00001422636,0.00001992733,0.0001395235,0.00001017538,0.0001529212],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009253805,"threshold_uncertainty_score":0.4240587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01710911962369718,"score_gpt":0.2875806278211641,"score_spread":0.2704715081974669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}