{"id":"W3185171385","doi":"10.1182/blood.2021011101","title":"Prognostic value of minimal residual disease negativity in myeloma: combined analysis of POLLUX, CASTOR, ALCYONE, and MAIA","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Calgary","funders":"National Cancer Institute","keywords":"Internal medicine; Medicine; Hazard ratio; Oncology; Multiple myeloma; Daratumumab; Proportional hazards model; Progression-free survival; Minimal residual disease; Confidence interval; Overall survival; Lenalidomide; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009584955,0.000515645,0.00155493,0.001337029,0.0003596465,0.001394861,0.000820419,0.000519417,0.0007311211],"category_scores_gemma":[0.008251724,0.0003467228,0.002009661,0.001186169,0.0006612763,0.0008038618,0.001057245,0.0007951375,0.0001036601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003780114,"about_ca_system_score_gemma":0.0003695836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009714183,"about_ca_topic_score_gemma":0.002350655,"domain_scores_codex":[0.9967611,0.001685507,0.0002978194,0.0005342726,0.0005764539,0.0001448987],"domain_scores_gemma":[0.9895067,0.004692083,0.003658769,0.0007729377,0.0006090748,0.000760638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.006069254,0.0000418129,0.9807885,0.0001474038,0.002963941,0.00006840799,0.0000671125,0.0004361552,0.001551253,0.00003068661,0.00006037145,0.007775063],"study_design_scores_gemma":[0.0002184146,0.001650998,0.9917409,0.0000348449,0.003130791,0.0004348301,0.00006790176,0.001215536,0.0007122863,0.0001197832,0.0006503189,0.00002339806],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892918,0.009467138,0.0003087719,0.00008844633,0.00001087654,0.00001764734,0.000355653,0.00000810487,0.0004515172],"genre_scores_gemma":[0.9992315,0.0002634103,0.0001593188,0.00002095817,0.00001953774,0.000006780583,0.0002238271,0.000002937024,0.0000716765],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009584955,"threshold_uncertainty_score":0.05069065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01710911962369718,"score_gpt":0.2875806278211641,"score_spread":0.2704715081974669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}