{"id":"W3185199445","doi":"10.1371/journal.ppat.1009795","title":"New and distinct chronic wasting disease strains associated with cervid polymorphism at codon 116 of the Prnp gene","year":2021,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; University of Saskatchewan; University of Alberta; University of Calgary","funders":"Genome Alberta; Canada Excellence Research Chairs, Government of Canada; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Alberta Agriculture and Forestry; Genome Canada","keywords":"Chronic wasting disease; Biology; PRNP; Virology; Pathogenesis; Gene; Proteases; Infectivity; Prion protein; Genotype; Genetics; Disease; Scrapie; Virus; Immunology; Medicine; Pathology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001033993,0.0005069004,0.0002790981,0.0004828675,0.0001815964,0.0002986484,0.0001842191,0.0002830315,0.0004884036],"category_scores_gemma":[0.0002411111,0.0001677189,0.0002829787,0.0002175322,0.0003203774,0.0001643324,0.0003827233,0.0006284224,0.0002091799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001668753,"about_ca_system_score_gemma":0.0001079488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005741111,"about_ca_topic_score_gemma":0.0005397939,"domain_scores_codex":[0.9998114,0.00001460844,0.00003130089,0.00007413862,0.00004311739,0.00002548406],"domain_scores_gemma":[0.9997055,0.00003178046,0.0001192479,0.00003330904,0.00003192768,0.00007815238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003537905,0.00006035027,0.009816161,0.00003201769,0.00001864696,0.0007415049,0.00006903848,0.00001537663,0.9876264,0.00005765037,0.0000353199,0.001173852],"study_design_scores_gemma":[0.0001006746,0.001644112,0.6589658,0.00004319369,0.0001446152,0.04366926,0.0002725958,0.0008751228,0.2913707,0.0002222332,0.002645086,0.00004656476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988976,0.0002770511,0.0003187628,0.0000123423,0.00000725102,0.00001739555,0.0001644002,0.000007902053,0.0002972715],"genre_scores_gemma":[0.9961345,0.0004620925,0.001538449,0.00004964432,0.00001453645,0.00002114704,0.001032544,0.0000149767,0.0007321044],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005741111,"threshold_uncertainty_score":0.001633883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01157968843756744,"score_gpt":0.203605906351318,"score_spread":0.1920262179137506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}