{"id":"W3185199445","doi":"10.1371/journal.ppat.1009795","title":"New and distinct chronic wasting disease strains associated with cervid polymorphism at codon 116 of the Prnp gene","year":2021,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; University of Saskatchewan; University of Alberta; University of Calgary","funders":"Genome Alberta; Canada Excellence Research Chairs, Government of Canada; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Alberta Agriculture and Forestry; Genome Canada","keywords":"Chronic wasting disease; Biology; PRNP; Virology; Pathogenesis; Gene; Proteases; Infectivity; Prion protein; Genotype; Genetics; Disease; Scrapie; Virus; Immunology; Medicine; Pathology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006046683,0.0001432429,0.0001372134,0.00001104534,0.0001449384,0.0000172811,0.0001227339,0.0000646428,0.00007775584],"category_scores_gemma":[0.0002574876,0.0001075399,0.00009306517,0.00009996337,0.00006084286,0.000002902133,0.0002707137,0.0000584186,9.698796e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003857077,"about_ca_system_score_gemma":0.0003596093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004685687,"about_ca_topic_score_gemma":0.00008931809,"domain_scores_codex":[0.9990629,0.00008542067,0.0001513893,0.0003099747,0.0001686064,0.000221698],"domain_scores_gemma":[0.9992526,0.00001619514,0.0001276753,0.0003433337,0.00006952411,0.0001907233],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003649342,0.00006322628,0.06514557,0.0000763783,0.0001128335,0.00002732388,0.00003138446,0.00002982893,0.9322622,0.0000149289,0.0000850626,0.002114804],"study_design_scores_gemma":[0.001170651,0.0001801609,0.3684357,0.0004009965,0.0003316843,0.00001854763,0.00003285711,0.0002437006,0.6281229,0.00005523023,0.00067515,0.0003324606],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820276,0.01684464,0.0001584383,0.0002136785,0.00003343403,0.0001707425,0.0004611961,0.0000105435,0.00007970693],"genre_scores_gemma":[0.9984034,0.0004916407,0.0002011913,0.00008377669,0.0001415578,0.000009816637,0.0002011481,0.00002524245,0.0004422416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3041393,"threshold_uncertainty_score":0.438535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01157968843756744,"score_gpt":0.203605906351318,"score_spread":0.1920262179137506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}