{"id":"W3185213439","doi":"10.1007/s00401-021-02343-x","title":"Cross-platform transcriptional profiling identifies common and distinct molecular pathologies in Lewy body diseases","year":2021,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Genomics and Rare Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"NIHR Imperial Biomedical Research Centre; Medical Research Council; Fonds de Recherche du Québec - Santé; Wellcome; Imperial College London; Edmond J. Safra Philanthropic Foundation; Wolfson Foundation; Dolby Family Ventures; Rosetrees Trust; Parkinson's UK; UK Dementia Research Institute; National Institute for Health and Care Research; UK Research and Innovation; Wellcome Trust","keywords":"Lewy body; Profiling (computer programming); Biology; Lewy body disease; Pathology; Computational biology; Medicine; Neuroscience; Dementia; Dementia with Lewy bodies; Disease; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001670578,0.0001926165,0.0002630105,0.0003566725,0.000175221,0.0003557334,0.00009523802,0.0002223909,0.0005386085],"category_scores_gemma":[0.0003364006,0.0001190683,0.000197324,0.0002087678,0.00028055,0.0001235269,0.0003192413,0.0002535216,0.0002047955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001508744,"about_ca_system_score_gemma":0.0001237669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008788229,"about_ca_topic_score_gemma":0.002510816,"domain_scores_codex":[0.9998272,0.00001616397,0.00001100766,0.00008316277,0.00003601918,0.00002655425],"domain_scores_gemma":[0.9998546,0.00003513962,0.00004121517,0.00001598756,0.00003555251,0.0000175014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001133591,0.000006875615,0.006907979,0.0000284382,0.00001444287,0.00007082261,0.0001110837,0.00006869713,0.9905899,0.00004257289,0.00002417015,0.002021722],"study_design_scores_gemma":[0.00002383504,0.0004840041,0.5989889,0.00004009465,0.0002091354,0.001791262,0.0008778021,0.003650879,0.3900434,0.0006708846,0.003196743,0.00002304388],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951288,0.0005038802,0.00303019,0.00003842743,0.000005454839,0.00001422017,0.0006613386,0.00002787203,0.0005898818],"genre_scores_gemma":[0.9940795,0.0003841799,0.003250772,0.00009773086,0.000007145497,0.00003163089,0.001509098,0.00002124833,0.0006188287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008788229,"threshold_uncertainty_score":0.001801848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01273079086794836,"score_gpt":0.2620692699545211,"score_spread":0.2493384790865727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}