{"id":"W3185237584","doi":"10.3389/fcell.2021.607332","title":"The BMP2 Signaling Axis Promotes Invasive Differentiation of Human Trophoblasts","year":2021,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"Reproductive System and Pregnancy","field":"Immunology and Microbiology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Science and Technology Program of Zhejiang Province; Canadian Institutes of Health Research; Natural Science Foundation of Zhejiang Province; National Natural Science Foundation of China","keywords":"Trophoblast; Blastocyst; Biology; Bone morphogenetic protein 2; Andrology; Embryo; Cell biology; Downregulation and upregulation; Inner cell mass; Placenta; Embryonic stem cell; Embryogenesis; Pregnancy; Immunology; Medicine; Fetus; Genetics; In vitro; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001586855,0.00027153,0.0001778336,0.0003140467,0.0001600457,0.0003293147,0.00006386178,0.0001508466,0.002306168],"category_scores_gemma":[0.0001226224,0.0001417544,0.0002354566,0.000155449,0.0001264207,0.0001192402,0.0002337972,0.000377406,0.0005256645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000175701,"about_ca_system_score_gemma":0.0003333312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00123876,"about_ca_topic_score_gemma":0.001697928,"domain_scores_codex":[0.9998869,0.0000195872,0.000008024923,0.00001659614,0.000040967,0.00002789596],"domain_scores_gemma":[0.9999646,0.000006493412,0.000006221317,0.000003164135,0.000008239979,0.00001129433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002933631,0.00003203272,0.001621228,0.0001790696,0.00001499844,0.0002329629,0.0000704645,0.0001045756,0.9894667,0.0003152475,0.0004554944,0.007213786],"study_design_scores_gemma":[0.00007816692,0.000492121,0.04319445,0.00005174732,0.00007946786,0.001375793,0.0002614594,0.002142582,0.9198342,0.0003669718,0.03210689,0.0000161417],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9634479,0.01369271,0.006593902,0.0004216899,0.0001332484,0.00009418585,0.001943481,0.0002483406,0.01342454],"genre_scores_gemma":[0.985539,0.004303202,0.00238873,0.0001847142,0.00002958153,0.0000591376,0.001286325,0.00003181393,0.006177469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002306168,"threshold_uncertainty_score":0.007714868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009916466358623775,"score_gpt":0.2101651534954602,"score_spread":0.2002486871368364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}