{"id":"W3185252607","doi":"10.1016/j.neurobiolaging.2021.07.013","title":"CSF neurofilament light may predict progression from amnestic mild cognitive impairment to Alzheimer's disease dementia","year":2021,"lang":"en","type":"article","venue":"Neurobiology of Aging","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Mount Sinai Hospital","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Dementia; Biomarker; Neurodegeneration; Cerebrospinal fluid; Cohort; Internal medicine; Medicine; Alzheimer's disease; Oncology; Frontotemporal dementia; Disease; Psychology; Pathology; Neuroscience; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005029354,0.0004272281,0.0002680731,0.0006799251,0.0002923715,0.0004441212,0.0001656766,0.0003466419,0.0007551983],"category_scores_gemma":[0.002223794,0.0001587571,0.0001843138,0.0002190127,0.0001986398,0.0003418162,0.0002679645,0.0004227556,0.0001880567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001976241,"about_ca_system_score_gemma":0.0001642533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002976514,"about_ca_topic_score_gemma":0.004041391,"domain_scores_codex":[0.9998976,0.00002299181,0.00001374611,0.0000254167,0.00002146105,0.00001883585],"domain_scores_gemma":[0.9990954,0.0001707814,0.0003980618,0.00003865813,0.0001163822,0.0001807529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006522503,0.00008818395,0.9948547,0.000008208426,0.00003550532,0.00009065607,0.00007803804,0.00003940034,0.0011139,0.000006234573,0.00005891985,0.002973957],"study_design_scores_gemma":[0.00001004026,0.0002848762,0.9989306,0.000003921409,0.00001791551,0.0002159615,0.00005446579,0.0001618958,0.0002222555,0.00002554175,0.00006994465,0.000002664543],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996376,0.0001404299,0.00003565796,0.0000108365,0.000003927745,0.000003367826,0.0000354224,0.000003540016,0.0001292767],"genre_scores_gemma":[0.9996243,0.00005924062,0.00007665934,0.000010324,0.00000533252,0.000003128922,0.00008950494,6.293118e-7,0.0001309345],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002976514,"threshold_uncertainty_score":0.005918384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02214003477798064,"score_gpt":0.3291347302437496,"score_spread":0.3069946954657689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}