{"id":"W3185315144","doi":"10.1158/1078-0432.ccr-21-1034","title":"FDA Approval Summary: Osimertinib for Adjuvant Treatment of Surgically Resected Non–Small Cell Lung Cancer, a Collaborative Project Orbis Review","year":2021,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"","keywords":"Osimertinib; Medicine; Internal medicine; Lung cancer; Oncology; Population; Placebo; non-small cell lung cancer (NSCLC); Cancer; Surgery; Family medicine; Pathology; Adenocarcinoma; Alternative medicine; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003561748,0.0007343751,0.0007322235,0.001490468,0.0004052263,0.001786856,0.0009087182,0.002733998,0.02466422],"category_scores_gemma":[0.003764647,0.0001836231,0.0008625293,0.001275841,0.0004275964,0.0009222716,0.0003727882,0.001963525,0.01029631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001529769,"about_ca_system_score_gemma":0.004218938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002656456,"about_ca_topic_score_gemma":0.006744192,"domain_scores_codex":[0.9987856,0.0003368568,0.0001132942,0.0001256174,0.0005371203,0.0001015513],"domain_scores_gemma":[0.997169,0.0005104571,0.0004565645,0.0000693332,0.001513311,0.0002813514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001635983,0.00004932683,0.0001620735,0.001858759,0.0000386545,0.00009229477,0.00001904042,0.00007984628,0.0005821124,0.002177679,0.8143611,0.1804156],"study_design_scores_gemma":[0.0001917139,0.0001269762,0.001041193,0.001290619,0.00005826853,0.0001272518,0.00001523244,0.00004169183,0.0001613631,0.0003433119,0.9965953,0.000007085566],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"other","genre_scores_codex":[0.004230808,0.5699536,0.002156615,0.09084487,0.03539957,0.002112278,0.0104804,0.0005960443,0.2842258],"genre_scores_gemma":[0.03222741,0.5432345,0.00406093,0.0873378,0.0188897,0.001751933,0.01174884,0.0002250926,0.3005238],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.02466422,"threshold_uncertainty_score":0.08251005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2000128509856096,"score_gpt":0.5691318612122892,"score_spread":0.3691190102266796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}