{"id":"W3185372058","doi":"10.1186/s13223-021-00574-x","title":"Transcutaneous penetration of a single-chain variable fragment (scFv) compared to a full-size antibody: potential tool for atopic dermatitis (AD) treatment","year":2021,"lang":"en","type":"article","venue":"Allergy Asthma and Clinical Immunology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Centre National de la Recherche Scientifique; Ministère de l'Enseignement Supérieur et de la Recherche; Association Nationale de la Recherche et de la Technologie; Institut National de la Santé et de la Recherche Médicale","keywords":"Atopic dermatitis; Stratum corneum; Antibody; Penetration (warfare); Dermis; Human skin; Single-chain variable fragment; In vivo; Psoriasis; Papillary dermis; Ex vivo; Medicine; Immunology; Chemistry; Molecular biology; In vitro; Monoclonal antibody; Pathology; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001837655,0.0002409595,0.0001869707,0.0002088654,0.00006821757,0.0001918496,0.0001977691,0.000316303,0.0009384767],"category_scores_gemma":[0.000136812,0.00007934622,0.0002262059,0.0001007119,0.0001485906,0.0002215665,0.0001215266,0.0003568323,0.0001333211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001767981,"about_ca_system_score_gemma":0.00009685571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004497635,"about_ca_topic_score_gemma":0.0003694811,"domain_scores_codex":[0.9998899,0.00002926911,0.000004979539,0.0000229076,0.00003369786,0.00001928085],"domain_scores_gemma":[0.9999266,0.00002584721,0.00002123181,0.000005011901,0.00001245287,0.000008970067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008377617,0.00004283008,0.0001210423,0.00006911346,0.000004811197,0.00003125708,0.00000707572,0.00005911069,0.9936455,0.00005196396,0.00004070627,0.005842783],"study_design_scores_gemma":[0.00002046255,0.001596779,0.003009905,0.00001037029,0.00005014863,0.0005680842,0.00002706482,0.001188952,0.9913204,0.00005576416,0.002146769,0.000005355455],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.971606,0.01473684,0.01144435,0.0002381155,0.00007403552,0.00005371707,0.0001018071,0.00009109652,0.001654104],"genre_scores_gemma":[0.9920503,0.003020495,0.003681391,0.00006900021,0.00001504773,0.00001895988,0.00006155481,0.000005799911,0.001077387],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009384767,"threshold_uncertainty_score":0.003139496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01785303353145026,"score_gpt":0.3032190893053651,"score_spread":0.2853660557739149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}