{"id":"W3185502700","doi":"10.1101/2021.07.21.21260588","title":"Low CD4/CD8 ratio predicts cancer risk among adults with HIV","year":2021,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Viral-associated cancers and disorders","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Institute of Neurological Disorders and Stroke; National Institute of Nursing Research; Health Resources and Services Administration; National Human Genome Research Institute; National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Institute on Aging; National Cancer Institute; National Institute on Alcohol Abuse and Alcoholism; National Institutes of Health; Government of Alberta; Agency for Healthcare Research and Quality; National Institute on Deafness and Other Communication Disorders; National Institute on Drug Abuse; National Institute of Dental and Craniofacial Research; Centers for Disease Control and Prevention","keywords":"Medicine; Hazard ratio; Interquartile range; Internal medicine; Cancer; Lung cancer; Confidence interval; CD4-CD8 Ratio; Oncology; Colorectal cancer; Gastroenterology; CD8; Immunology; Immune system; Lymphocyte subsets","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002537022,0.0001713696,0.0001351027,0.0003388072,0.0003734425,0.0005395398,0.0003756133,0.0002255279,0.002066153],"category_scores_gemma":[0.001539303,0.0001614411,0.0002386243,0.0006344879,0.0001646527,0.0002944814,0.0003042206,0.0006336747,0.0001581077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004972601,"about_ca_system_score_gemma":0.0008005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.08107413,"about_ca_topic_score_gemma":0.0795524,"domain_scores_codex":[0.9998499,0.00002410254,0.00001362249,0.000045281,0.00002739246,0.00003965349],"domain_scores_gemma":[0.9994086,0.0001004854,0.0002265242,0.00003356799,0.0001230118,0.000107826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00002897315,0.000008089483,0.9988787,0.000005965671,0.000016927,0.00001233083,0.000009652408,0.00005219943,0.00002751523,0.00001429027,0.0001585359,0.0007868173],"study_design_scores_gemma":[0.000006818706,0.0000330863,0.9976138,0.00001716279,0.00004295292,0.0001287048,0.000116959,0.001448593,0.00008534481,0.000075957,0.00042739,0.000003324123],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960243,0.0007959803,0.0001778206,0.0001831509,0.0000166093,0.00001042264,0.001945284,0.00001168791,0.0008347178],"genre_scores_gemma":[0.9990306,0.000123638,0.00008162702,0.00002737554,0.00001037735,0.000003658513,0.0005391195,0.000001306661,0.0001823595],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08107413,"threshold_uncertainty_score":0.1612045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007727472333410909,"score_gpt":0.2377407439274326,"score_spread":0.2300132715940217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}