{"id":"W3185510385","doi":"10.1038/s41571-021-00544-7","title":"Adjuvant olaparib — should all patients with breast cancer have genetic testing?","year":2021,"lang":"en","type":"review","venue":"Nature Reviews Clinical Oncology","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's College Hospital","funders":"","keywords":"Olaparib; Breast cancer; Medicine; Oncology; Genetic testing; Adjuvant; Internal medicine; Mutation; Cancer; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.001216093,0.0009564749,0.004965577,0.00009429058,0.00009562294,0.00004001149,0.0009556584,0.004657264,0.0002201245],"category_scores_gemma":[0.002182593,0.0006478041,0.001296038,0.0004658589,0.0003561305,0.000005838848,0.000514171,0.003209004,0.0000728017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005256065,"about_ca_system_score_gemma":0.004766585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001557902,"about_ca_topic_score_gemma":0.0002431338,"domain_scores_codex":[0.9924411,0.001921965,0.00266204,0.001905572,0.0003880119,0.0006812976],"domain_scores_gemma":[0.9945214,0.0005974278,0.002096005,0.001524882,0.0008903837,0.0003698634],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000319792,0.0004136757,0.002044185,0.002432469,0.0006848968,0.00002986793,0.000003403515,0.00000269733,6.79013e-7,0.000003774886,0.0397157,0.9546367],"study_design_scores_gemma":[0.0009427734,0.0007915586,0.001340134,0.005927471,0.002945749,0.000154302,0.000001815783,0.000001447126,8.466427e-7,0.000003604919,0.9871266,0.0007636874],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003862063,0.9941186,0.00003825568,0.0002711175,0.00196521,0.002265993,0.0005407449,0.00002245591,0.000738969],"genre_scores_gemma":[0.0000130018,0.9815311,0.008122205,0.004271646,0.00266102,0.001032414,0.001686955,0.000176178,0.0005055245],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.953873,"threshold_uncertainty_score":0.9995973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1445943947971782,"score_gpt":0.487743436468439,"score_spread":0.3431490416712608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}