{"id":"W3185532990","doi":"10.1126/sciadv.abf8660","title":"FUS-ALS mutants alter FMRP phase separation equilibrium and impair protein translation","year":2021,"lang":"en","type":"article","venue":"Science Advances","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"UCLH Biomedical Research Centre; Medical Research Council; Rosetrees Trust; Motor Neurone Disease Association; University College London Hospitals NHS Foundation Trust; Canadian Institutes of Health Research; National Institute for Health and Care Research; Wellcome Trust","keywords":"Translation (biology); Mutant; Cell biology; Biology; Chemistry; Genetics; Messenger RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008692549,0.0004631609,0.0001681858,0.0002164615,0.0001616612,0.0001539716,0.0001467275,0.0002909839,0.001115927],"category_scores_gemma":[0.0001071646,0.0001166937,0.0001981043,0.0001314142,0.0003333465,0.0001657727,0.0001961293,0.0002446964,0.0003262656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003232401,"about_ca_system_score_gemma":0.0001419032,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000729938,"about_ca_topic_score_gemma":0.001247511,"domain_scores_codex":[0.999923,0.00001285835,0.00001249763,0.0000162511,0.00002095872,0.00001437106],"domain_scores_gemma":[0.9999143,0.00001931388,0.00003560726,0.000007895098,0.000004193267,0.00001866016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007146847,0.00001274157,0.00008249476,0.00001175189,0.000004239286,0.00007808272,0.000009527521,0.0000598156,0.9990402,0.0001614918,0.00001746663,0.0004506628],"study_design_scores_gemma":[0.00001356641,0.0001604393,0.001436252,0.000003171407,0.0000111352,0.0003774553,0.00001759893,0.0005446078,0.9961448,0.0001031467,0.001184224,0.000003610824],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949939,0.0005116728,0.003042037,0.00004947373,0.0000228191,0.00001994479,0.0003560532,0.0001201664,0.0008840205],"genre_scores_gemma":[0.9967141,0.0002484975,0.00149024,0.0000254904,0.000004846464,0.00001328036,0.0002724907,0.0000304002,0.001200477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001115927,"threshold_uncertainty_score":0.003733099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01193152993021913,"score_gpt":0.3358200566985348,"score_spread":0.3238885267683157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}