{"id":"W3185533154","doi":"10.2217/fon-2021-0370","title":"Prediction and Characterization of Diffuse Large B-Cell Lymphoma Cell-of-Origin Subtypes Using Targeted Sequencing","year":2021,"lang":"en","type":"article","venue":"Future Oncology","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Foundation Medicine; H. Lundbeck A/S; Amgen; TG Therapeutics; Genentech; Celgene; F. Hoffmann-La Roche","keywords":"Exome sequencing; Somatic cell; DNA sequencing; Germinal center; Carcinogenesis; Diffuse large B-cell lymphoma; Biology; Ion semiconductor sequencing; Computational biology; Cell of origin; Germline mutation; Genetics; Cell; DNA; Mutation; Gene; B cell; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002912931,0.000235361,0.0003105995,0.001647804,0.0002043136,0.0007952523,0.0001964829,0.0004099827,0.0008779629],"category_scores_gemma":[0.0007477166,0.0001197031,0.0001678112,0.000553363,0.0001401397,0.0001748492,0.0003115373,0.000186929,0.0004230818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001779973,"about_ca_system_score_gemma":0.0001746874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001188645,"about_ca_topic_score_gemma":0.002447627,"domain_scores_codex":[0.999773,0.00003081848,0.00002108532,0.00007371728,0.00005636431,0.00004503227],"domain_scores_gemma":[0.9996275,0.0001073312,0.00008957456,0.00004278197,0.00007853292,0.00005421182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006275544,0.00006782293,0.6804011,0.0001234466,0.00007797607,0.0006094386,0.0001908202,0.0006099496,0.2722938,0.0002721025,0.0002646681,0.04446133],"study_design_scores_gemma":[0.00004199418,0.0003803055,0.884302,0.00006924581,0.000301849,0.006134035,0.0007671299,0.01445808,0.0833951,0.0007340288,0.009396657,0.0000195488],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938258,0.0008561668,0.003760101,0.00002737685,0.000004258216,0.00004415179,0.0005588652,0.00004377483,0.0008795848],"genre_scores_gemma":[0.9943558,0.0003634913,0.003788945,0.00003444167,0.000008872531,0.00003078343,0.001001865,0.00001402231,0.0004018807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001647804,"threshold_uncertainty_score":0.002937138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01892371372503405,"score_gpt":0.262826755363928,"score_spread":0.243903041638894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}