{"id":"W3185533176","doi":"10.3389/fmicb.2021.691731","title":"Treponema pallidum Disrupts VE-Cadherin Intercellular Junctions and Traverses Endothelial Barriers Using a Cholesterol-Dependent Mechanism","year":2021,"lang":"en","type":"article","venue":"Frontiers in Microbiology","topic":"Syphilis Diagnosis and Treatment","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Michael Smith Health Research BC","keywords":"Treponema; VE-cadherin; Endocytosis; Cell biology; Biology; Endothelium; Cell junction; Filipin; Tight junction; Paracellular transport; Intracellular; Transcellular; Microbiology; Cadherin; Cholesterol; Immunology; Syphilis; Permeability (electromagnetism); Receptor; Cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001132979,0.000225679,0.0004945851,0.0001610196,0.00008371069,0.00002253351,0.00005928045,0.0002050275,0.0002683499],"category_scores_gemma":[0.00006254415,0.0002053381,0.0001152008,0.0001143593,0.0001361399,0.00004711564,0.00007243908,0.0001993355,0.00001128365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002185677,"about_ca_system_score_gemma":0.0001113375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007105552,"about_ca_topic_score_gemma":0.0001511259,"domain_scores_codex":[0.9986434,0.0001371392,0.0003200668,0.0005061094,0.00005359172,0.0003397047],"domain_scores_gemma":[0.999454,0.00002267214,0.00007088238,0.0002602401,0.00004082716,0.0001513515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002358911,0.0004442163,0.1627011,0.00006654779,0.0005293414,0.001256927,0.001929161,0.00001306162,0.8288881,0.0001331599,0.001391606,0.002410909],"study_design_scores_gemma":[0.02828051,0.0018863,0.03186511,0.000915365,0.001721749,0.00976743,0.01867377,0.0007965133,0.8514834,0.001434701,0.05174965,0.001425494],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928064,0.001497508,0.002592291,0.0003898919,0.002173848,0.0003133873,0.0001183483,0.00002842505,0.00007985062],"genre_scores_gemma":[0.9924046,0.0005772709,0.00551253,0.0005026279,0.00009929686,0.0000387746,0.0001074568,0.00003082678,0.0007266433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.130836,"threshold_uncertainty_score":0.8373445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01720525074478768,"score_gpt":0.2533749230206912,"score_spread":0.2361696722759035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}