{"id":"W3185533176","doi":"10.3389/fmicb.2021.691731","title":"Treponema pallidum Disrupts VE-Cadherin Intercellular Junctions and Traverses Endothelial Barriers Using a Cholesterol-Dependent Mechanism","year":2021,"lang":"en","type":"article","venue":"Frontiers in Microbiology","topic":"Syphilis Diagnosis and Treatment","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Michael Smith Health Research BC","keywords":"Treponema; VE-cadherin; Endocytosis; Cell biology; Biology; Endothelium; Cell junction; Filipin; Tight junction; Paracellular transport; Intracellular; Transcellular; Microbiology; Cadherin; Cholesterol; Immunology; Syphilis; Permeability (electromagnetism); Receptor; Cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001443325,0.000229663,0.0002286859,0.0001493252,0.0001581175,0.000418989,0.0002075134,0.0004791125,0.0006560457],"category_scores_gemma":[0.0001820605,0.0001213257,0.0002672557,0.00009991926,0.0001828799,0.0002809576,0.0002235555,0.0005573555,0.0001992848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003217266,"about_ca_system_score_gemma":0.00018623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009199993,"about_ca_topic_score_gemma":0.00118943,"domain_scores_codex":[0.9998336,0.0000348922,0.0000105065,0.00002171748,0.00004370473,0.00005553443],"domain_scores_gemma":[0.9999235,0.0000177108,0.00002608244,0.00001062345,0.00001174824,0.00001028179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000563375,0.00002596385,0.0003220042,0.00005652602,0.000007401015,0.00009831752,0.0000192614,0.00006082434,0.9974712,0.0002108177,0.00003678082,0.001634622],"study_design_scores_gemma":[0.00001950831,0.000445108,0.01145801,0.00001608474,0.0000175913,0.0007548186,0.00005274775,0.002051661,0.9823042,0.0001331611,0.002740201,0.000006909958],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902229,0.002889442,0.004391854,0.0002449143,0.00002963927,0.00004136773,0.0001186254,0.00006058747,0.002000704],"genre_scores_gemma":[0.9959685,0.0008147327,0.001774471,0.00006162142,0.00000671802,0.00001789341,0.00006301935,0.000004203453,0.001288897],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009199993,"threshold_uncertainty_score":0.002334356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01720525074478768,"score_gpt":0.2533749230206912,"score_spread":0.2361696722759035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}