{"id":"W3185536495","doi":"10.1111/cas.15075","title":"Tumor suppressor miR‐193a‐3p enhances efficacy of BRAF/MEK inhibitors in <i>BRAF</i>‐mutated colorectal cancer","year":2021,"lang":"en","type":"article","venue":"Cancer Science","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"","keywords":"Cancer research; Trametinib; MCL1; Dabrafenib; MAPK/ERK pathway; MEK inhibitor; Cetuximab; Colorectal cancer; EGFR inhibitors; Epidermal growth factor receptor; Cancer; microRNA; KRAS; Cyclin-dependent kinase 6; Biology; Cell cycle; Medicine; Kinase; Vemurafenib; Downregulation and upregulation; Internal medicine; Melanoma; Cell biology; Cyclin-dependent kinase; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002141837,0.0002996489,0.0004560094,0.0002248522,0.0001763326,0.0003368497,0.0001694618,0.000231113,0.001003351],"category_scores_gemma":[0.0002490983,0.0001848707,0.0004217176,0.0001261606,0.0002003245,0.0001927425,0.00017559,0.0005875265,0.0003200281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003123406,"about_ca_system_score_gemma":0.0003023317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006533291,"about_ca_topic_score_gemma":0.0009171832,"domain_scores_codex":[0.9998658,0.00002194943,0.00001541937,0.00002103096,0.00004544321,0.00003049653],"domain_scores_gemma":[0.9999155,0.00002095541,0.00002259885,0.000006440444,0.00001135614,0.00002320132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009849622,0.0001678871,0.0007546531,0.00007094429,0.00002526094,0.00007950182,0.00002107037,0.0001835041,0.9911872,0.00007229086,0.0002294657,0.006223345],"study_design_scores_gemma":[0.000163809,0.002450224,0.01074797,0.000008947402,0.0001226241,0.0005050888,0.00003204542,0.00233257,0.97989,0.00008444729,0.003648308,0.00001386757],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945898,0.002163315,0.001192426,0.0001571714,0.00007894263,0.00004041742,0.0002235391,0.0001432385,0.001411079],"genre_scores_gemma":[0.997538,0.0006801335,0.0008760047,0.00008188753,0.00001309873,0.00003010243,0.0001900678,0.00001708758,0.000573672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001003351,"threshold_uncertainty_score":0.003356576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00941443090138921,"score_gpt":0.273504839717919,"score_spread":0.2640904088165298,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}