{"id":"W3185588022","doi":"10.1073/pnas.2105447118","title":"Evolution of a σ–(c-di-GMP)–anti-σ switch","year":2021,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Biological and Environmental Research; Basic Energy Sciences; Biotechnology and Biological Sciences Research Council; Office of Science; National Institutes of Health; Research Councils UK; Lawrence Berkeley National Laboratory; National Institute of General Medical Sciences; Directorate for Biological Sciences; Office of the President, University of California; U.S. Department of Energy","keywords":"Cyclic gmp; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005335894,0.00005258365,0.00009048752,0.00005299906,0.00007263061,0.000006110302,0.0002541869,0.00007433204,0.000009118222],"category_scores_gemma":[0.0003966846,0.0000395033,0.00007585862,0.0003991566,0.0003156358,0.00001317017,0.0001102287,0.00004857639,2.799705e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001077423,"about_ca_system_score_gemma":0.00008087186,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002656914,"about_ca_topic_score_gemma":6.056107e-8,"domain_scores_codex":[0.9990453,0.000006084916,0.0002162512,0.00016353,0.0004895469,0.00007929582],"domain_scores_gemma":[0.9992706,0.00001052712,0.0002699129,0.000008545657,0.0004224297,0.00001803204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000006580814,0.00002502444,0.004914086,0.0000380336,0.0000086089,2.663268e-9,0.00001433398,0.0001820433,0.9737237,0.02083583,0.00013089,0.000120836],"study_design_scores_gemma":[0.0001179428,0.00002263099,0.03440263,0.00005324609,0.000006307645,0.000006710014,0.00007019251,0.0004192145,0.9560039,0.008515615,0.000338499,0.00004313522],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960167,0.000765431,0.00003240381,0.0006958438,0.00001205364,0.00007075111,0.000009102436,0.000002283026,0.00239547],"genre_scores_gemma":[0.9985926,0.00002701507,0.001125422,0.00006307702,0.00006031713,0.000003055802,4.617086e-7,0.00000226341,0.0001257926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02948854,"threshold_uncertainty_score":0.1610898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02344874000574595,"score_gpt":0.2849578010173023,"score_spread":0.2615090610115564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}