{"id":"W3185614498","doi":"10.1096/fj.202100427r","title":"Analyzing the impact of CFP1 mutational landscape on epigenetic signaling","year":2021,"lang":"en","type":"review","venue":"The FASEB Journal","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Epigenetics; Acetylation; Histone; DNA methylation; Methylation; Biology; Carcinogenesis; Human multitasking; Computational biology; Genetics; Posttranslational modification; Epigenesis; Cell biology; DNA; Cancer; Biochemistry; Neuroscience; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009355978,0.0002565087,0.0005138676,0.00008240517,0.0002358721,0.0000807016,0.0003974342,0.0001740977,0.0001245651],"category_scores_gemma":[0.0001674741,0.0001242341,0.0009717063,0.0001971987,0.00006526295,0.000001799724,0.00007254852,0.0004214989,0.000006229371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002977735,"about_ca_system_score_gemma":0.0005539365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005237137,"about_ca_topic_score_gemma":0.000001507315,"domain_scores_codex":[0.9982529,0.0005692485,0.0005375125,0.0002016218,0.0002243982,0.0002143155],"domain_scores_gemma":[0.9985543,0.0001935151,0.0006325007,0.000377331,0.00017075,0.0000715606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000417443,0.0001346673,0.0003275611,0.0005010701,0.002467437,0.00003164399,0.0001361931,0.01997994,0.0344113,0.00006455243,0.0006220181,0.9412819],"study_design_scores_gemma":[0.003279595,0.005895192,0.001588387,0.02475777,0.009726282,0.00263115,0.0007403396,0.001022483,0.2144998,0.002539693,0.7292356,0.004083689],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01942232,0.9789083,0.001057673,0.00001892466,0.0001451495,0.0001576487,0.00004247332,0.000001672073,0.0002458276],"genre_scores_gemma":[0.04950051,0.9492514,0.0000844806,0.000008834046,0.0008122615,0.000006941395,0.000189893,0.00003333307,0.0001123472],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9371982,"threshold_uncertainty_score":0.5066119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03774383058448928,"score_gpt":0.3497781264601478,"score_spread":0.3120342958756586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}