{"id":"W3185614567","doi":"10.1093/cvr/cvab247","title":"The size of apolipoprotein (a) is an independent determinant of the reduction in lipoprotein (a) induced by PCSK9 inhibitors","year":2021,"lang":"en","type":"article","venue":"Cardiovascular Research","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"Agence Nationale de la Recherche","keywords":"PCSK9; Apolipoprotein B; Lipoprotein; Lipoprotein(a); Reduction (mathematics); Internal medicine; LDL receptor; Endocrinology; Chemistry; Medicine; Cholesterol; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002293999,0.0002684114,0.0003430576,0.0002124473,0.0001366961,0.0002990536,0.000121002,0.0002140979,0.001422073],"category_scores_gemma":[0.0007384226,0.0001423458,0.000314491,0.0001681316,0.000205515,0.0001432368,0.0001536302,0.0004697998,0.0002323656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002292919,"about_ca_system_score_gemma":0.0001280613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002918741,"about_ca_topic_score_gemma":0.0003527552,"domain_scores_codex":[0.9997928,0.00004709557,0.00002792959,0.00004619149,0.00005119557,0.00003484383],"domain_scores_gemma":[0.9994179,0.0001226767,0.0002556448,0.00004183556,0.00005750804,0.0001044101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.02504127,0.0007319638,0.3211865,0.0002450004,0.0005235486,0.0008129484,0.0001426964,0.0005588671,0.600229,0.0001369695,0.0006523695,0.04973883],"study_design_scores_gemma":[0.0004061268,0.005359496,0.914964,0.00001570905,0.0002275731,0.001528183,0.00008300324,0.0008863964,0.07539084,0.00009020905,0.0010341,0.00001447492],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985681,0.0007558998,0.0001566381,0.0000421347,0.000009222379,0.000008209417,0.00009630564,0.00001035664,0.0003531852],"genre_scores_gemma":[0.9993004,0.0001614205,0.0001807405,0.00002612589,0.00001176157,0.000007058065,0.0001293639,0.00000276594,0.0001803625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001422073,"threshold_uncertainty_score":0.004757345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04925802966700194,"score_gpt":0.3364357134192971,"score_spread":0.2871776837522951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}