{"id":"W3185626009","doi":"10.1016/j.jlr.2021.100096","title":"PCSK9 is not secreted from mature differentiated intestinal cells","year":2021,"lang":"en","type":"article","venue":"Journal of Lipid Research","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Fondazione Cariplo; Fondation Leducq; Agence Nationale de la Recherche","keywords":"PCSK9; Secretion; Kexin; Biology; Ex vivo; LDL receptor; Proprotein convertase; Internal medicine; Intestinal mucosa; Endocrinology; Cell biology; In vivo; Cholesterol; Lipoprotein; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000143469,0.0002125203,0.0003802612,0.0001597379,0.000118631,0.0006894624,0.0001644313,0.0002981306,0.001581724],"category_scores_gemma":[0.0002323521,0.0001680646,0.0002293763,0.0001703225,0.0002095488,0.0002943557,0.0002270135,0.001000564,0.001234196],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003360927,"about_ca_system_score_gemma":0.000387101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006915627,"about_ca_topic_score_gemma":0.0007598704,"domain_scores_codex":[0.9997252,0.00002311118,0.00003858277,0.00007293915,0.00009105447,0.00004908602],"domain_scores_gemma":[0.9997388,0.00004597751,0.00003883232,0.00005794967,0.00005770271,0.00006083101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000167172,0.000009552105,0.0002913272,0.00003795443,0.000003634974,0.00006656782,0.00001276534,0.000009744314,0.998073,0.00006335751,0.00004947797,0.001215412],"study_design_scores_gemma":[0.00002426464,0.0001696746,0.01069216,0.00001178486,0.00001838581,0.0005055044,0.00004918763,0.0004219271,0.9774362,0.00007684131,0.01058812,0.000005895677],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9746562,0.004732769,0.01099154,0.0003747104,0.0002157252,0.00007624758,0.003755902,0.0002611805,0.004935712],"genre_scores_gemma":[0.9729519,0.002000044,0.004485128,0.0002257065,0.0000419796,0.00006232422,0.006186316,0.00007565774,0.0139708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001581724,"threshold_uncertainty_score":0.005291402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07202484813705237,"score_gpt":0.3652262734819696,"score_spread":0.2932014253449172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}