{"id":"W3185700649","doi":"10.1007/s12015-021-10208-9","title":"MSC-Derived Extracellular Vesicles in Preclinical Animal Models of Bone Injury: A Systematic Review and Meta-Analysis","year":2021,"lang":"en","type":"review","venue":"Stem Cell Reviews and Reports","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"Élisabeth Bruyère Hospital; University of Ottawa; Canadian Blood Services; Ottawa Hospital","funders":"Canadian Blood Services","keywords":"Mesenchymal stem cell; Meta-analysis; Medicine; Stromal cell; Bone healing; Bioinformatics; Oncology; Internal medicine; Pathology; Surgery; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00541023,0.001421619,0.01126653,0.003728979,0.0002395466,0.002241719,0.001577088,0.001318652,0.003499304],"category_scores_gemma":[0.0119261,0.0006119049,0.01065641,0.005104439,0.0005597432,0.001097154,0.00109852,0.001036351,0.0003926767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001135989,"about_ca_system_score_gemma":0.002802236,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002945604,"about_ca_topic_score_gemma":0.009496257,"domain_scores_codex":[0.9973119,0.0007274277,0.001018803,0.000398939,0.000442164,0.0001008601],"domain_scores_gemma":[0.9920639,0.005419897,0.001690314,0.0002046463,0.0005198977,0.000101345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.002028134,0.00004718056,0.002578533,0.783108,0.1321192,0.0001105838,0.00009986915,0.0005151483,0.0007209228,0.0003057574,0.002906185,0.0754606],"study_design_scores_gemma":[0.001147066,0.0005860696,0.0100375,0.1492223,0.811531,0.0003413676,0.0001790378,0.0002136039,0.0004707078,0.0007173502,0.02546136,0.00009250701],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001129842,0.9978861,0.0001852509,0.00008480134,0.00005656162,0.00005963754,0.000480735,0.000006914814,0.0001102043],"genre_scores_gemma":[0.01727176,0.9809657,0.0005365609,0.0004581627,0.0000798917,0.0001339864,0.0004254365,0.00001048164,0.0001179305],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01126653,"threshold_uncertainty_score":0.02861232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08343073642494124,"score_gpt":0.3558712183323011,"score_spread":0.2724404819073599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}