{"id":"W3185715241","doi":"10.1136/bcr-2021-242075","title":"Presumed complement-mediated, checkpoint inhibitor-induced, thrombotic microangiopathy in a patient with metastatic melanoma","year":2021,"lang":"en","type":"article","venue":"BMJ Case Reports","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Thrombotic microangiopathy; Medicine; ADAMTS13; Nivolumab; Ipilimumab; Pembrolizumab; Eculizumab; Melanoma; Internal medicine; Adverse effect; Immunotherapy; Atypical hemolytic uremic syndrome; Oncology; Gastroenterology; Thrombotic thrombocytopenic purpura; Immunology; Complement system; Cancer; Immune system; Cancer research; Platelet","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003592962,0.001017153,0.0008450891,0.001813746,0.002005064,0.001065026,0.0008344674,0.003257851,0.00193819],"category_scores_gemma":[0.002806932,0.0006964715,0.0007065436,0.001047563,0.001096246,0.00129016,0.0007777557,0.002463252,0.0005276556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001043564,"about_ca_system_score_gemma":0.000723697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002826293,"about_ca_topic_score_gemma":0.00313747,"domain_scores_codex":[0.9996307,0.00004694781,0.00003730206,0.00009299728,0.00006421101,0.0001278644],"domain_scores_gemma":[0.9989052,0.0003391182,0.0002200306,0.00006740918,0.00007331118,0.0003948441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.00004625777,0.00003201815,0.01177934,0.00003119849,0.000007126842,0.9861647,0.0001955727,0.00004521298,0.0004899961,0.0001033807,0.0002762121,0.0008289178],"study_design_scores_gemma":[0.000009929044,0.00007584791,0.008228378,0.00001885159,0.00001207811,0.9906936,0.0001054129,0.0002070684,0.0002165715,0.00008290012,0.0003426766,0.00000672584],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9791875,0.005386252,0.001512965,0.00444954,0.0002785115,0.0001492063,0.000224247,0.0001076482,0.008704116],"genre_scores_gemma":[0.996659,0.001147841,0.0004466106,0.0006348875,0.0004375705,0.0000112778,0.00005130233,0.000009635231,0.00060178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003257851,"threshold_uncertainty_score":0.007571578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02884246737456103,"score_gpt":0.2818951137762346,"score_spread":0.2530526464016736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}