{"id":"W3185715241","doi":"10.1136/bcr-2021-242075","title":"Presumed complement-mediated, checkpoint inhibitor-induced, thrombotic microangiopathy in a patient with metastatic melanoma","year":2021,"lang":"en","type":"article","venue":"BMJ Case Reports","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Thrombotic microangiopathy; Medicine; ADAMTS13; Nivolumab; Ipilimumab; Pembrolizumab; Eculizumab; Melanoma; Internal medicine; Adverse effect; Immunotherapy; Atypical hemolytic uremic syndrome; Oncology; Gastroenterology; Thrombotic thrombocytopenic purpura; Immunology; Complement system; Cancer; Immune system; Cancer research; Platelet","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004679051,0.0003445614,0.0006469888,0.0001786355,0.0001393468,0.00003738471,0.00006788738,0.00008730416,0.001339572],"category_scores_gemma":[0.0002781152,0.0002985117,0.0001543672,0.0003339802,0.00008398842,0.0001056877,0.0002254441,0.000213989,0.000159321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000178575,"about_ca_system_score_gemma":0.0004391442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000659656,"about_ca_topic_score_gemma":0.001902276,"domain_scores_codex":[0.996685,0.0005335691,0.001314909,0.000721171,0.0001459855,0.0005993361],"domain_scores_gemma":[0.9980558,0.0002058198,0.0006054089,0.0008681021,0.0001845383,0.00008030771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.0001371192,0.0008259171,0.01644137,0.0001967587,0.0006233917,0.8541586,0.0009154856,0.00001814534,0.1237617,0.000027933,0.001940253,0.0009533361],"study_design_scores_gemma":[0.002684387,0.0004276356,0.006978794,0.0005168105,0.000281773,0.8644151,0.003996992,0.00001006773,0.1151226,0.00005517265,0.004926156,0.0005845095],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946108,0.002232321,0.00002744272,0.0001631046,0.0006387461,0.00165366,0.0000761086,0.00008626167,0.0005115267],"genre_scores_gemma":[0.9985243,0.000005778171,0.0002622952,0.0001055851,0.00002863723,0.0003174458,0.0006077692,0.00003950516,0.0001086603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01025651,"threshold_uncertainty_score":0.9999467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02884246737456103,"score_gpt":0.2818951137762346,"score_spread":0.2530526464016736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}