{"id":"W3185731138","doi":"10.1158/1541-7786.mcr-21-0259","title":"Chemical Screen Identifies Diverse and Novel Histone Deacetylase Inhibitors as Repressors of NUT Function: Implications for NUT Carcinoma Pathogenesis and Treatment","year":2021,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Optometric Education Trust Fund","funders":"National Institute of General Medical Sciences; National Cancer Institute","keywords":"Bromodomain; BRD4; Chromatin; Cancer research; Histone deacetylase; Biology; Histone; Acetylation; Demethylase; Histone acetyltransferase; Panobinostat; EZH2; Chemistry; Cell biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001861603,0.0005439869,0.0006011018,0.0005686637,0.0001919302,0.0003920947,0.0004057871,0.000281313,0.001906737],"category_scores_gemma":[0.0001066597,0.0001886544,0.0004141917,0.0004101318,0.0001309084,0.0001796831,0.0002140295,0.000455421,0.000460629],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004725084,"about_ca_system_score_gemma":0.0003092882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007543784,"about_ca_topic_score_gemma":0.002876713,"domain_scores_codex":[0.9999021,0.00001215434,0.000008387011,0.00002059718,0.00003996308,0.00001686506],"domain_scores_gemma":[0.9999295,0.00001235822,0.00001448826,0.000006674315,0.00001954156,0.00001737623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003811295,0.0003291461,0.001500787,0.0002485773,0.00007211357,0.0001303628,0.00001599248,0.001158198,0.9783496,0.0002433495,0.0005076847,0.01706317],"study_design_scores_gemma":[0.0005015313,0.00531094,0.01066693,0.00003960111,0.000408339,0.0008829346,0.00004970476,0.005362335,0.9603274,0.0001819601,0.01623501,0.00003321741],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9583886,0.01929166,0.008096029,0.0006571538,0.0001074151,0.0006257869,0.004597791,0.0005646285,0.007670852],"genre_scores_gemma":[0.977078,0.009842012,0.005013704,0.0002085347,0.00002204756,0.0001647669,0.003211973,0.00002863323,0.004430454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001906737,"threshold_uncertainty_score":0.006378651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05512560490331853,"score_gpt":0.3661578280758201,"score_spread":0.3110322231725016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}