{"id":"W3185731138","doi":"10.1158/1541-7786.mcr-21-0259","title":"Chemical Screen Identifies Diverse and Novel Histone Deacetylase Inhibitors as Repressors of NUT Function: Implications for NUT Carcinoma Pathogenesis and Treatment","year":2021,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Optometric Education Trust Fund","funders":"National Institute of General Medical Sciences; National Cancer Institute","keywords":"Bromodomain; BRD4; Chromatin; Cancer research; Histone deacetylase; Biology; Histone; Acetylation; Demethylase; Histone acetyltransferase; Panobinostat; EZH2; Chemistry; Cell biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001861573,0.000128286,0.0001564356,0.00007442388,0.0001637516,0.00003536691,0.00008488977,0.0001242206,0.00001766964],"category_scores_gemma":[0.0001767795,0.00012879,0.00008677767,0.0001652872,0.000298027,0.000008223639,0.000197466,0.00006589406,8.091357e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006686685,"about_ca_system_score_gemma":0.0002384095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004284456,"about_ca_topic_score_gemma":0.00009136821,"domain_scores_codex":[0.9988055,0.00007176888,0.0001938212,0.0005131549,0.0001873833,0.0002283819],"domain_scores_gemma":[0.9989902,0.00002435772,0.00005564845,0.0003829092,0.0004134441,0.0001334393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001664578,0.00009516437,0.00153566,0.00003847073,0.00007418341,0.000003778531,0.00003874757,0.000003629233,0.9901528,0.0005682612,0.0008897042,0.006433165],"study_design_scores_gemma":[0.001062974,0.0002085937,0.002961742,0.00001988388,0.0000428449,0.00001432142,0.0001492577,0.00001245746,0.9869763,0.0001367313,0.008289887,0.0001249584],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895986,0.007104392,0.001506676,0.0009302208,0.00005093489,0.0004607892,0.0001937101,0.00000678085,0.0001479475],"genre_scores_gemma":[0.99704,0.000747589,0.000473425,0.00006883472,0.0001106551,0.0004023148,0.0002090337,0.00002265848,0.0009255391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007441401,"threshold_uncertainty_score":0.5251905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05512560490331853,"score_gpt":0.3661578280758201,"score_spread":0.3110322231725016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}