{"id":"W3185790707","doi":"10.1128/spectrum.00439-21","title":"A Novel Small Molecule Inhibits Hepatitis C Virus Propagation in Cell Culture","year":2021,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Hepatitis C virus research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Canadian Institutes of Health Research; Memorial University of Newfoundland; Government of Canada","keywords":"NS5B; Hepatitis C virus; Virology; Virus; Viral replication; Biology; NS2-3 protease; Cell culture; RNA; RNA polymerase; Hepacivirus; Polymerase; NS3; Viral life cycle; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001643732,0.0001876323,0.0003495705,0.0001742665,0.00005604952,0.00002041495,0.0001047727,0.00029112,0.0005051361],"category_scores_gemma":[0.0001374248,0.0001759666,0.0000842152,0.0005071364,0.0001096859,0.00004278143,0.000128339,0.0005570013,0.0004271099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002499574,"about_ca_system_score_gemma":0.0003670028,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001332362,"about_ca_topic_score_gemma":0.02135046,"domain_scores_codex":[0.9984398,0.0001239192,0.0003209155,0.0005012859,0.00007941552,0.0005346105],"domain_scores_gemma":[0.9993696,0.00002697142,0.00005907949,0.0003214241,0.0001127797,0.0001101893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005030428,0.0003605457,0.03181057,0.00006385858,0.00002138645,0.0005062587,0.0002929944,0.000001964925,0.9652206,0.0001000039,0.001237731,0.0003338263],"study_design_scores_gemma":[0.001827686,0.0002625237,0.009117271,0.00007697921,0.00001546075,0.0003783496,0.00003019498,0.00007413796,0.9752996,0.00003910441,0.01269866,0.0001800238],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862218,0.0007320085,0.0005159367,0.00239883,0.0001217136,0.0004906899,0.0001051711,0.00005940577,0.009354381],"genre_scores_gemma":[0.9901648,0.000577073,0.002272237,0.001370295,0.0001129089,0.00004383867,0.0005743716,0.00003679363,0.004847691],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0226933,"threshold_uncertainty_score":0.9965073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01752174144796937,"score_gpt":0.2610958206859652,"score_spread":0.2435740792379958,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}