{"id":"W3185790707","doi":"10.1128/spectrum.00439-21","title":"A Novel Small Molecule Inhibits Hepatitis C Virus Propagation in Cell Culture","year":2021,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Hepatitis C virus research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Canadian Institutes of Health Research; Memorial University of Newfoundland; Government of Canada","keywords":"NS5B; Hepatitis C virus; Virology; Virus; Viral replication; Biology; NS2-3 protease; Cell culture; RNA; RNA polymerase; Hepacivirus; Polymerase; NS3; Viral life cycle; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001501296,0.0004834263,0.0003781212,0.000360993,0.0002727955,0.000255951,0.000314082,0.0003681917,0.002684302],"category_scores_gemma":[0.0001083323,0.0001573591,0.0003478843,0.0001754024,0.0002591993,0.0001894849,0.0002118953,0.0006748446,0.0007723163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001785562,"about_ca_system_score_gemma":0.0003880165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004975048,"about_ca_topic_score_gemma":0.001668952,"domain_scores_codex":[0.9999236,0.00001193028,0.000008482497,0.00001357745,0.00002390953,0.00001852423],"domain_scores_gemma":[0.9999282,0.00002763597,0.000009790611,0.000007398719,0.000006708025,0.00002028739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003143867,0.0003154156,0.000117449,0.0002206858,0.00001317581,0.0002496747,0.00004941162,0.0002003325,0.9783895,0.00071944,0.0005074769,0.01890294],"study_design_scores_gemma":[0.0007017927,0.008391576,0.002328231,0.00004028937,0.00005118291,0.001268761,0.00003018767,0.0009743509,0.9533546,0.0002244178,0.0326021,0.00003264367],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9180421,0.03029599,0.01872041,0.001008983,0.0009782907,0.001048536,0.001265341,0.0007422214,0.02789814],"genre_scores_gemma":[0.9371496,0.02298549,0.02040779,0.0004670231,0.0003254897,0.0005878561,0.001771529,0.00004942124,0.01625584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002684302,"threshold_uncertainty_score":0.008979857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01752174144796937,"score_gpt":0.2610958206859652,"score_spread":0.2435740792379958,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}