{"id":"W3185822896","doi":"10.1021/acs.jmedchem.1c00506","title":"Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma","year":2021,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of New Brunswick; Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research; Government of Ontario","keywords":"Chemistry; Kinase; G protein-coupled receptor kinase; IC50; Small molecule; Drug discovery; Pharmacology; Receptor; In vitro; Biochemistry; Biology; G protein-coupled receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002782232,0.0003430012,0.0003760327,0.000288689,0.0001506763,0.0002018885,0.0004874555,0.0002844664,0.001651241],"category_scores_gemma":[0.0001764531,0.0001911809,0.0002415502,0.0002080497,0.0001481441,0.0002054854,0.0001985695,0.0003998804,0.0004835673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002562712,"about_ca_system_score_gemma":0.0003087891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003771663,"about_ca_topic_score_gemma":0.001043623,"domain_scores_codex":[0.9999032,0.00001970477,0.000009729819,0.00001343002,0.00002846586,0.00002536475],"domain_scores_gemma":[0.9999293,0.000009954757,0.00001906381,0.000005323034,0.00001704242,0.0000192706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000540389,0.0004483925,0.0002712286,0.0004020835,0.00003416986,0.0003494509,0.0001067031,0.004302823,0.9655042,0.0008595822,0.000531722,0.0266494],"study_design_scores_gemma":[0.001586827,0.01346119,0.002821612,0.00006816047,0.0001015172,0.001053896,0.00005791571,0.005964584,0.9420161,0.0003299032,0.03247425,0.00006392815],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9440556,0.01266033,0.03048522,0.0004810466,0.0001200985,0.002090378,0.001906975,0.0002870215,0.007913368],"genre_scores_gemma":[0.96921,0.007026456,0.01850097,0.0001492863,0.00003710731,0.0003276705,0.001097829,0.00002618108,0.003624585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001651241,"threshold_uncertainty_score":0.00552392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02476041281924111,"score_gpt":0.2789612372945284,"score_spread":0.2542008244752872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}