{"id":"W3185851404","doi":"10.1038/s41467-021-24712-6","title":"Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Ferroptosis and cancer prognosis","field":"Medicine","cited_by":251,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Deutsche Forschungsgemeinschaft","keywords":"Necroptosis; RIPK1; GPX4; Acute kidney injury; Acute tubular necrosis; Necrosis; Kidney; Cancer research; Medicine; Programmed cell death; Cell biology; Biology; Pathology; Glutathione peroxidase; Oxidative stress; Internal medicine; Apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000344555,0.0007493754,0.0006071875,0.0009761499,0.0003367791,0.0004150237,0.0005320872,0.0008827207,0.002427167],"category_scores_gemma":[0.0001533241,0.0003002417,0.0005320082,0.0003059662,0.0006584087,0.0004273619,0.0003335763,0.00164144,0.0006478535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006023139,"about_ca_system_score_gemma":0.0003963499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004075356,"about_ca_topic_score_gemma":0.0009506748,"domain_scores_codex":[0.9994955,0.00009321972,0.00007200908,0.0001167265,0.0001011268,0.0001214134],"domain_scores_gemma":[0.9995017,0.00004166216,0.0001909117,0.00004603413,0.0000364253,0.000183278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003507701,0.0001146855,0.0001207085,0.0000367466,0.000007329511,0.00005030258,0.00001834472,0.00006707301,0.998163,0.0001409566,0.00005454646,0.0008754095],"study_design_scores_gemma":[0.00005867362,0.0008363375,0.0009954507,0.000009457159,0.000019192,0.0001973175,0.00002513544,0.0005338126,0.9958093,0.00005146092,0.001458203,0.00000560994],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861798,0.001404173,0.007921743,0.0005855419,0.0001402442,0.0002138136,0.001314207,0.0006075841,0.001632793],"genre_scores_gemma":[0.9812991,0.0009638201,0.009616772,0.0001844067,0.00003050397,0.0003366291,0.001014387,0.0001166096,0.006437762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002427167,"threshold_uncertainty_score":0.008119643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01676176154543003,"score_gpt":0.2804080596466896,"score_spread":0.2636462981012596,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}