{"id":"W3185868240","doi":"10.1152/physrev.00008.2021","title":"Altered islet prohormone processing: a cause or consequence of diabetes?","year":2021,"lang":"en","type":"review","venue":"Physiological Reviews","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Vancouver Coastal Health Research Institute; Government of Canada","keywords":"Proinsulin; Prohormone; Proglucagon; Prohormone convertase; Internal medicine; Endocrinology; Glucagon; Biology; Diabetes mellitus; Insulin; Type 2 diabetes; Hormone; Medicine; Glucagon-like peptide-1","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000359073,0.0003484006,0.000643207,0.0005471754,0.0001434887,0.0007718748,0.0004136971,0.0009857354,0.001812357],"category_scores_gemma":[0.0006629823,0.0001223121,0.0002032529,0.0004506344,0.0007621079,0.0009590517,0.0003119088,0.0008628413,0.0004944463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002226958,"about_ca_system_score_gemma":0.0001667518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002897003,"about_ca_topic_score_gemma":0.0001769969,"domain_scores_codex":[0.9998521,0.00001451483,0.00001902763,0.00004638617,0.00003702064,0.00003088948],"domain_scores_gemma":[0.9996521,0.00008406096,0.0001231211,0.00003319329,0.00003959422,0.00006787517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003320888,0.0003399947,0.5767151,0.002352006,0.0003259728,0.0810029,0.0008929138,0.0002922631,0.1598183,0.004828863,0.004949464,0.1651614],"study_design_scores_gemma":[0.0002203567,0.001220844,0.682269,0.0005604668,0.0008441206,0.1863744,0.002585772,0.001448714,0.06651376,0.01250104,0.04536319,0.00009845306],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.8127326,0.1623126,0.00575001,0.009423745,0.001324696,0.00003356796,0.0004812758,0.0002561591,0.007685285],"genre_scores_gemma":[0.95202,0.04207245,0.001113051,0.001392811,0.001196567,0.00001104834,0.0002490189,0.00002528791,0.001919786],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.001812357,"threshold_uncertainty_score":0.006062984,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3144532909745159,"score_gpt":0.4312972043778671,"score_spread":0.1168439134033513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}