{"id":"W3185868240","doi":"10.1152/physrev.00008.2021","title":"Altered islet prohormone processing: a cause or consequence of diabetes?","year":2021,"lang":"en","type":"review","venue":"Physiological Reviews","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Vancouver Coastal Health Research Institute; Government of Canada","keywords":"Proinsulin; Prohormone; Proglucagon; Prohormone convertase; Internal medicine; Endocrinology; Glucagon; Biology; Diabetes mellitus; Insulin; Type 2 diabetes; Hormone; Medicine; Glucagon-like peptide-1","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000467858,0.0005909188,0.006888079,0.00008619,0.00004771092,0.0000193113,0.000225878,0.0003468286,0.001032294],"category_scores_gemma":[0.004946426,0.0002843053,0.001041346,0.0007308885,0.0002827765,0.0000493406,0.0001260999,0.0005168399,0.000218444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000763298,"about_ca_system_score_gemma":0.0006415917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001149162,"about_ca_topic_score_gemma":8.278566e-8,"domain_scores_codex":[0.9964776,0.0005684636,0.001556152,0.0007106355,0.0002600942,0.000427066],"domain_scores_gemma":[0.9973847,0.00039744,0.001052366,0.0007323403,0.0001828047,0.0002503738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002326369,0.0004828785,0.00000440275,0.1225851,0.0002713352,0.000106995,0.00001021,2.598404e-8,0.001303945,0.00004358374,0.03835862,0.8368096],"study_design_scores_gemma":[0.0002701939,0.0005021603,0.00001439076,0.06571192,0.001975904,0.00007621598,0.000003135681,0.00000472706,0.00004430603,0.00002102762,0.9310862,0.0002898586],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002279639,0.9968029,0.000008552536,0.00004327449,0.00009922737,0.002305865,0.00003378433,0.00005989058,0.0004186049],"genre_scores_gemma":[0.00003456746,0.9955662,0.0009840021,0.000661288,0.0003019368,0.0009084284,0.0003308203,0.00003547205,0.001177237],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8927276,"threshold_uncertainty_score":0.9999609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3144532909745159,"score_gpt":0.4312972043778671,"score_spread":0.1168439134033513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}